精神分裂症患者血清性激素水平与其精神症状和情绪状态的相关性分析

Relationship between Serum Sex Hormone Levels and Their Mental Symptoms and Emotional State in Schizophrenic Patients

目的:探讨精神分裂症患者血清性激素水平与其精神症状和情绪状态的关系。方法:选择广东省湛江市第三人民医院2019年1-11月收治的精神分裂症患者50例纳入研究组。选择同期雷州市人民医院体检健康者50例作为对照组。所有研究对象于晨间空腹抽静脉血5 mL,离心分离血清,采用全自动微粒子化学发光免疫分析系统及相应试剂盒对其血清泌乳素(PRL)、睾酮(TSTO)和雌二醇(E2)水平进行检测,精神症状采用阳性与阴性症状量表(PANSS)和简明精神病量表(BPRS)评定。采用Pearson分析研究组性激素水平与PANSS量表评分、BPRS各因子及总分的相关性。结果:研究组男性和女性的血清PRL、TSTO、E2水平均显著低于对照组,差异均有统计学意义(P<0.05)。研究组阴性症状评分、阳性症状评分、一般精神病理得分、PANSS总分分别为(24.56±5.24)、(16.95±4.23)、(37.22±5.52)、(77.86±10.23)分。研究组血清TSTO、E2、PRL水平与PANSS各项评分及总分均呈负相关(P<0.05)。研究组焦虑抑郁、缺乏活力、思维障碍、激活性、敌对猜疑评分分别为(1.39±0.26)、(3.69±0.13)、(3.22±0.23)、(2.59±0.26)、(2.06±0.32)分。血清TSTO、E2、PRL水平与焦虑抑郁、缺乏活力、思维障碍、激活性评分及BPRS总分均呈负相关(P<0.05)。结论:血清性激素与精神分裂症患者的精神症状存在一定的相关性,影响性激素水平的是患者的精神症状和情绪状态,因此,血清性激素水平可应用于对精神分裂症患者精神症状和情绪状态的风险评估。

Objective:To investigate the relationship between serum sex hormone levels and mental symptoms and emotional state in schizophrenic patients.Method:A total of 50 schizophrenic patients admitted to the Third People’s Hospital of Zhanjiang City from January to November 2019 were enrolled in the study group,50 cases of physical health in Leizhou People’s Hospital during the same period were selected as the control group.All the research objects in the morning on an empty stomach phlebotomize 5 mL,centrifugal separation serum,the serum prolactin(PRL),testo sterone(TSTO)and estradiol(E2)levels were detected by automatic microparticle chemiluminescence immunoassay system and corresponding kits,the positive and negative symptom scale(PANSS)and brief psychiatric scale(BPRS)were used to evaluate the mental symptoms.The correlation between sex hormone level and PANSS score,BPRS factors and total score were analyzed by person correlation analysis.Result:The serum PRL,TSTO and E2 levels of men and women in the study group were significantly lower than those in the control group,the differences were statistically significant(P<0.05).The negative symptom score,positive symptom score,general psychopathology score and PANSS total score of the study group were(24.56±5.24),(16.95±4.23),(37.22±5.52)and(77.86±10.23)scores respectively.The levels of serum TSTO,E2 and PRL in study group were negatively correlated with PANSS scores and total scores(P<0.05).The scores of anxiety and depression,lack of vitality,thinking disorder,activation and hostility in the study group were(1.39±0.26),(3.69±0.13),(3.22±0.23),(2.59±0.26),(2.06±0.32)scores respectively.Serum TSTO,E2,PRL levels were negatively correlated with anxiety and depression,lack of vitality,thinking disorder,activation score and total score of BPRS(P<0.05).Conclusion:There is a certain correlation between serum sex hormones and the mental symptoms of schizophrenia patients,the mental symptoms and emotional state of patients affect the level of sex hormones,therefore,serum sex hormone levels can be used to assess the risk of schizophrenia patients with mental symptoms and emotional state.