改良性电休克联合药物治疗对精神分裂症患者认知功能及记忆力的影响

Effect of Modified Electrical Shock Combined with Drug Therapy on Cognitive Function and Memory in Patients with Schizophrenia

目的:探讨改良性电休克联合药物治疗对精神分裂症(SP)患者认知功能及记忆力的影响。方法:选择2017年9月-2019年8月本院收治的82例SP患者,按随机数字表法将其分为观察组和对照组,各41例。对照组接受帕利哌酮缓释片治疗,观察组在对照组基础上联用改良性电休克治疗。比较两组临床疗效、阳性症状和阴性症状量表(PANSS)评分、认知功能及记忆力情况。结果:观察组的总有效率为92.68%,高于对照组的75.61%,差异有统计学意义(P<0.05);治疗后,两组PANSS评分均下降,且观察组低于对照组,差异均有统计学意义(P<0.05);治疗后,观察组WMS、MMSE、MoCA评分均高于对照组,差异均有统计学意义(P<0.05)。结论:改良性电休克联合药物治疗SP效果确切,可改善认知功能,对记忆力影响较小。

Objective:To investigate the effect of modified electrical shock combined with drug therapy on cognitive function and memory in patients with schizophrenia(SP).Method:A total of 82 patients with SP admitted to our hospital from September 2017 to August 2019 were selected.According to the random number table method,they were divided into observation group and control group,41 cases in each group.The control group was treated with Parepiperone Sustained Release Tablets,the observation group was combined with modified electrical shock therapy on the basis of the control group.Clinical efficacy,positive symptoms and negative symptoms scale(PANSS)scores,cognitive function and memory were compared between the two groups.Result:The total effective rate in the observation group was 92.68%,higher than 75.61%in the control group,with statistically significant difference(P<0.05).After treatment,PANSS score decreased in both groups,and the observation group was lower than that of the control group,the differences were statistically significant(P<0.05).After treatment,WMS,MMSE and MoCA scores of the observation group were all higher than those of the control group,with statistically significant differences(P<0.05).Conclusion:The effect of modified electrical shock combined with drugs in the treatment of SP is exact,which can improve cognitive function and has little effect on memory.