高频重复经颅磁刺激辅助治疗混合性焦虑和抑郁障碍患者的有效性和安全性研究

Effectiveness and Safety of High Frequency Repetitive Transcranial Magnetic Stimulation in the Adjuvant Treatment of Patients with Mixed Anxiety and Depression Disorder

目的:探讨高频重复经颅磁刺激辅助治疗混合性焦虑和抑郁障碍患者的有效性及安全性。方法:选取2018年1月-2019年1月于本院就诊的混合性焦虑和抑郁障碍患者120例,按随机数字表法将其分为观察组与对照组,每组60例。对照组采用帕罗西汀治疗并以伪线圈给予假刺激;观察组采用帕罗西汀并以高频重复经颅磁刺激辅助治疗。比较两组治疗前及治疗1、2、4、6周后汉密顿焦虑量表(HAMA)与汉密顿抑郁量表(HAMD)评分;比较两组临床疗效及不良反应发生情况。结果:治疗1、2、4、6周后,观察组HAMA与HAMD评分均低于对照组(P<0.05)。观察组治疗总有效率高于对照组(P<0.05)。观察组不良反应发生率低于对照组(P<0.05)。结论:高频重复经颅磁刺激辅助治疗混合性焦虑和抑郁障碍可明显改善患者的焦虑、抑郁状态,提高临床效果,减少不良反应的发生,值得在临床上推广应用。

Objective:To investigate the effectiveness and safety of high frequency repetitive transcranial magnetic stimulation in the adjuvant treatment of patients with mixed anxiety and depression disorder.Method:A total of 120 patients with mixed anxiety and depression disorder admitted to our hospital from January 2018 to January 2019 were selected.They were divided into observation group and control group according to random number method,with 60 patients in each group.The control group was treated with Paroxetine and given false stimulation with pseudo coil.The observation group was treated with Paroxetine and high frequency repetitive transcranial magnetic stimulation.Hamilton anxiety scale(HAMA)and Hamilton depression scale(HAMD)scores before and after 1,2,4,and 6 weeks for treatment were compared between the two groups.The clinical efficacy and adverse reactions were compared between the two groups.Result:After 1,2,4,and 6 weeks for treatment,HAMA and HAMD scores in the observation group were lower than those in the control group(P<0.05).The total effective rate of the observation group was higher than that of the control group(P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group(P<0.05).Conclusion:High frequency repetitive transcranial magnetic stimulation in the adjuvant treatment of patients with mixed anxiety and depression disorder can significantly improve patients’anxiety and depression,improve clinical efficacy,reduce the incidence of adverse reactions,which is worthy of clinical application.