舌下含服粉尘螨滴剂在儿童过敏性哮喘中的临床应用观察

Clinical Application of Sublingual Dermatophagoides Farinae Drops in Children with Allergic Asthma

目的:探讨舌下含服粉尘螨滴剂在儿童过敏性哮喘中的临床效果。方法:选取2016年10月-2019年3月明确诊断为尘螨变应原引起的IgE诱导的过敏性哮喘患者128例入组,随机分为治疗组(64例)和对照组(64例)。对照组患儿仅接受其他常规哮喘治疗,治疗组患儿在此基础上联合粉尘螨滴剂舌下含服进行特异性免疫治疗。比较两组患儿治疗前后的哮喘症状评分、用药评分、呼气峰流速值占正常预计值的百分比。结果:治疗后,观察组患儿哮喘症状评分、用药评分均较低,和治疗前、对照组对比,差异均有统计学意义(P<0.05)。治疗后,观察组患儿PEF%较高,和治疗前、对照组对比,差异均有统计学意义(P<0.05)。观察组患儿不良反应发生率和对照组相当,差异无统计学意义(P>0.05)。结论:舌下含服粉尘螨滴剂在儿童过敏性哮喘中的临床效果较好,可以改善患儿的哮喘症状评分、用药评分(PEF%),而且不增加患儿的不良反应,应用价值较高。

Objective:To investigate the clinical effect of sublingual Dermatophagoides Farinae Drops in children with allergic asthma.Method:From October 2016 to March 2019,128 patients with allergic asthma induced by IgE,which was definitely diagnosed as dust mite allergen were randomly divided into treatment group(64 cases)and control group(64 cases).The control group received only other routine asthma treatment,and the treatment group received specific immunotherapy combined with Dermatophagoides Farinae Drops under the tongue.Before and after treatment,the asthma symptoms scores,drug scores,and the percentage of peak expiratory flow rate(PEF%)in the normal predicted value of the two groups were statistically analyzed and compared.Result:The scores of asthma symptoms and medication in the observation group were lower than those in the control group(P<0.05).The percentage of peak expiratory flow rate in the observation group was higher than that in the control group(P<0.05).The incidence of adverse reactions in the observation group was similar to that in the control group,there was no significant difference(P>0.05).Conclusion:The clinical effect of sublingual Dermatophagoides Farinae Drops in children with allergic asthma is better.It can improve the asthma symptom score and drug use score(PEF),and it does not increase the adverse reactions of children.