FTS理念应用于结肠癌切除术后的效果及对患者血清炎性因子水平的的影响

Effects of FTS concept after colon cancer resection and its effect on serum IL-6, CRP and SAA levels in patients

目的:探讨加速康复外科(Fast track surgery,FTS)理念应用于结肠癌切除术后的效果及对患者血清淀粉样蛋白A(Serum amyloid A,SAA)、白细胞介素-6(Interleukin-6,IL-6)及C反应蛋白(C-reactive protein,CRP)水平的影响。方法:根据抽签分组法将我院2018年8月至2019年6月行结肠癌切除术的80例患者分为对照组(n=40例,接受常规围术期护理)和观察组(n=40例,应用FTS理念的围术期护理)。观察两组患者术后胃肠功能恢复情况时间、术后7 d采集患者空腹静脉血离心后经ELISA法检测患者炎性因子水平,术后1 d及术后3 d经视觉模拟评分量表(Visual analogue scale,VAS)评估患者疼痛情况。结果:观察组患者术后胃肠功能恢复时间明显短于对照组(P<0.05);术后7d血清IL-6、CRP以及SAA水平也明显低于对照组(P<0.05);且术后1 d及术后3 d VAS的分值也显著低于对照组(P<0.05)。结论:FTS理念应用于结肠癌切除术后的患者,可明显缩短胃肠功能恢复时间,减轻炎性水平并降低疼痛程度。

Objective:To investigate the effects of the concept of accelerated rehabilitation surgery(Fast Track Surgery,FTS)on colon cancer resection and its effect on serum amyloid A(Serum amyloid A,SAA),interleukin-6(Interleukin-6,IL-6)and C-reactive protein(C-reactive protein,CRP)levels in patients.Methods:According to the lottery grouping method,80 patients undergoing colon cancer resection in our hospital from August 2018 to June 2019 were divided into the control group(n=40 cases,receiving routine perioperative nursing)and the observation group(n=40 Example,perioperative nursing using the FTS concept).To observe the time of postoperative recovery of gastrointestinal function of the two groups,and to collect the fasting venous blood of the patients 7 days after the surgery,and then detect the level of inflammatory factors of the patients by ELISA method.The pain of the patients was evaluated by Visual analogue scale(VAS)scale 1 and 3 days after the surgery,and the pain was evaluated 1 and 3 days after the surgery.Results:The recovery time of gastrointestinal function in the observation group was significantly shorter than that in the control group(P<0.05).Serum levels of IL-6,CRP and SAA at 7 days after surgery were also significantly lower than those in the control group(P<0.05).Moreover,VAS scores on 1 and 3 days after surgery were significantly lower than those of the control group(P<0.05).Conclusion:The application of FTS concept in patients after colon cancer resection can shorten the recovery time of gastrointestinal function,reduce inflammatory level and reduce pain.