NMDA受体拮抗剂作为快速起效抗抑郁药物的研究进展

Progress in the Application of NMDA receptor antagonists in rapid-onset antidepressants

目前临床使用的传统抗抑郁药需要连续用药2-3周才能起效,不能有效的降低患者在抑郁症状发作期的自杀风险,对抑郁症患者非常不利。因此,抗抑郁药研发的热点集中在开发能快速改善抑郁患者症状发作期的自杀企图和自杀行为的药物。研究表明,NMDA受体拮抗剂对患者的抑郁症状有迅速的缓解作用,且维持较长时间。本文对快速起效抗抑郁药的研究进展作一综述,重点探讨NMDA受体系统在抗抑郁药中研究进展。

Traditional antidepressants in clinical use need to be continuously used for 2-3 weeks to take effect at present.It can’t effectively reduce the risk of suicide in patients with depressive episode,and is very unfavorable for depression patients.Therefore,the research and development of antidepressants focuses on the development of drugs that can rapidly improve suicide attempts and suicide behaviors of depressed patients.Research shows,NMDA receptor antagonists can relieve the depressive symptoms of the patients rapidly and maintain for a long time.This article reviews the research progress of antidepressants with rapid onset,and focuses on the research progress of NMDA receptor system in antidepressants.