纳洛酮联合胞磷胆碱治疗重症脑梗死的疗效及安全性分析

Efficacy and Safety of Naloxone Combined with Citicoline in the Treatment of Severe Cerebral Infarction

目的:针对在重症脑梗死患者的治疗中采用纳洛酮联合胞磷胆碱药物治疗的临床疗效以及药物治疗的安全性进行实验分析。方法:截取自2016年6月—2019年10月于本院治疗的重症脑梗死患者96例,将患者分为常规组(胞磷胆碱药物治疗)以及观察组(纳洛酮联合胞磷胆碱药物治疗),观察两组患者治疗后的临床疗效、生活质量评分以及不良反应出现率。结果:观察组患者治疗后,其临床疗效以及生活质量评分明显高于常规组患者,观察组患者不良反应发生率明显低于常规组患者,两组患者所有数据统计对比后均存在显著差距,表示差异有统计学意义(P<0.05)。结论:对重症脑梗死患者使用纳洛酮联合胞磷胆碱药物治疗,可在一定程度上帮助提高治疗效果,提升患者日常生存质量,同时有效避免患者治疗中出现不良反应,具有一定的安全性,值得临床借鉴。

Objective:To analyze the clinical efficacy and safety of naloxone combined with citicoline in the treatment of severe cerebral infarction.Methods:96 patients with severe cerebral infarction treated in our hospital from June 2016 to October 2019 were divided into routine group(citicoline drug treatment)and observation group(naloxone combined with citicoline drug treatment)to observe the clinical efficacy,quality of life score and the incidence of adverse reactions.Results:The clinical efficacy and quality of life of the patients in the observation group were significantly higher after treatment.For the patients in the conventional group,the incidence of adverse reactions in the observation group was significantly lower than that in the conventional group,and there was a significant difference between all the data of the two groups after statistical comparison,indicating statistical significance(P<0.05).Conclusion:The treatment of patients with severe cerebral infarction with naloxone combined with citicoline can help to improve the therapeutic effect,improve the quality of life of patients,and effectively avoid adverse reactions in the treatment of patients,which has certain safety and is worthy of clinical reference.