中国人群慢性牙周炎与口腔幽门螺杆菌感染相关性分析

Meta-analysis of the correlation between chronic periodontitis and oral helicobacter pylori infection in chinese population

目的:探讨口腔幽门螺杆菌感染与慢性牙周炎发生的相关性,为幽门螺杆菌致牙周炎的机制研究提供理论依据。方法:检索研究口腔幽门螺杆菌感染与慢性牙周炎相关性的文献,根据纳入文献的数据进行meta分析。病例-对照研究以OR值为效应量,meta分析合并效应量计算牙周炎组与牙周健康组口腔幽门螺杆菌感染的风险比。对牙周炎进行亚组分析,meta分析比较轻度、中度和重度牙周炎患者的口腔幽门螺杆菌感染的风险。结果:本研究共纳入研究19篇病例-对照研究,合并效应量后,总体OR值及其95%CI为4.34[3.23,5.82],Z检验P<0.00001,差异有统计学意义。亚组分析中度牙周炎和轻度牙周炎的口腔幽门螺杆菌感染率总效应量OR值及其95%CI为3.07[2.24,4.22],Z检验P<0.00001,差异有统计学意义。重度牙周炎和中度牙周炎的口腔幽门螺杆菌感染率总效应量OR及其95%CI为1.76[1.15,2.69],Z检验P=0.009,差异有统计学意义。结论:口腔幽门螺杆菌感染与慢性牙周炎发生具有强烈相关性,且感染率与牙周炎严重程度呈明显的相关性。即口腔幽门螺杆菌感染是牙周炎发生的危险因素。

Objective:To investigate the correlation between oral Helicobacter pylori infection and periodontitis,and to provide a theoretical basis for the mechanism of Helicobacter pylori-induced periodontitis.Methods:The literature on the correlation between oral Helicobacter pylori infection and periodontitis was searched and meta-analysis was conducted based on data included literature.In the case-control study,the OR value was used as the effect size to calculate the risk ratio of oral Helicobacter pylori infection in the periodontitis group and the periodontal health group.A subgroup analysis was performed for periodontitis.Meta analysis compared the risk of oral Helicobacter pylori infection in patients with mild to moderate periodontitis and severe periodontitis.Results:A total of 19 case-control studies were included in the study.After combining the effectors,the overall OR value and its 95%CI were 4.34[3.23,5.82],and the Z test,P<0.00001.The difference was statistically significant.The subgroup analysis of the total effect rate of oral Helicobacter pylori infection rate in moderate periodontitis and mild periodontitis and its 95%CI was 3.07[2.24,4.22],Z test,P<0.00001,the difference was statistically significant.The total effect rate OR value of 95%CI of oral Helicobacter pylori infection in severe periodontitis and moderate periodontitis was 1.76[1.15,2.69],Z test,P=0.009,the difference was statistically significant.Conclusions:Oral Helicobacter pylori infection has a strong correlation with the occurrence of periodontitis,and the infection rate is significantly correlated with the severity of periodontitis.That is,oral Helicobacter pylori infection is a risk factor for the development of periodontitis.