口腔鳞癌组织中长链非编码RNA对其发生发展机制的影响

Advances in the study on the mechanism of long-chain noncoding RNA in oral squamous cell carcinoma

口腔鳞状细胞癌是目前最常见的口腔恶性肿瘤之一,在近年来发病率逐年升高并有年轻化的趋势。OSCC的恶性程度高,OSCC患者的总体生存率在过去的很长一段时间并未得到有效改善,始终维持在50%左右。既往的口腔肿瘤研究者们多试图以优化临床治疗方法为突破口。他们花费大量的人力、物力在对治疗方法不断优化的探索上,他们不仅对手术、放疗、化疗等方法进行优化,同时也在探索治疗方法的优化组合。以期达到提高患者的生存率的目的,但让研究者感到遗憾的是优化临床治疗方案的结果目前并不理想。近年来随着分子生物学迅猛发展,大量研究发现长链非编码RNA(long non-coding RNA,LncRNA)在肿瘤细胞中异常表达,并在肿瘤发展进程中扮演重要的角色。因此,许多研究者逐渐意识到可以通过深入研究LncRNA在OSCC的分子发生机制层面的作用,进而分析OSCC发生和发展的可能机制。积极探索临床治疗OSCC的有效分子靶点对促进OSCC的早期发现、诊断及治疗都具有积极的意义。所以本文主要探讨在分子层面LncRNA对口腔鳞癌发生发展机制的影响的研究进展。

Oral squamous cell carcinoma(OSCC)is one of the most common oral malignancies.In recent years,the incidence rate has been increasing year by year and has a trend of getting younger.The overall survival rate of OSCC patients has not been effectively improved for a long time in the past,and has been maintained around 50%.In the past,oral cancer researchers tried to optimize the clinical treatment.They spend a lot of manpower and material resources on the exploration of continuous optimization of treatment methods.They not only optimize the operation,radiotherapy,chemotherapy and other methods,but also explore the optimal combination of treatment methods.In order to achieve the purpose of improving the survival rate of patients,but let the researchers regret that the results of optimizing the clinical treatment program is are not ideal at present.In recent years,with the rapid development of molecular biology,a large number of studies have found that long non coding RNA(LncRNA)is abnormally expressed in tumor cells,and plays an important role in the development of tumor.Therefore,many researchers gradually realize that it is of positive significance to study the role of LncRNA in the molecular mechanism of OSCC,Then analyze the possible mechanism of OSCC occurrence and development,and actively explore the effective target of clinical treatment of OSCC to promote the early detection,diagnosis and treatment of OSCC.So this paper mainly discusses the influence of LncRNA on the pathogenesis of OSCC.