急性脑梗死患者溶血磷脂酸水平与颈动脉斑块性质的相关性研究

Clinical observation on the correlation between LPA level and carotid plaque in patients with acute cerebral infarction

目的:探讨急性脑梗死(ACI)患者溶血磷脂酸(LPA)与颈动脉斑块性质的相关性。方法:选取江苏省中医药研究院住院符合诊断标准患者144例,不稳定斑块组86例、稳定斑块组58例,收集患者基线资料,测定各组LPA水平。结果:比较两组年龄、低密度脂蛋白胆固醇(LDL)、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL)、糖化血红蛋白、纤维蛋白原、血小板聚集率、颈动脉内膜中层厚度IMT、高血压、糖尿病、脑梗死病史、吸烟饮酒史的基线资料,两组间差异均无统计学意义(P>0.05),组间存在性别的统计学差异(P<0.05),不稳定斑块组LPA水平明显高于稳定斑块组,差异有统计学意义(P<0.05)。结论:提示在ACI患者中LPA水平与颈动脉斑块不稳定性密切相关。

Objective To investigate the correlation between lysophosphatidic acid(LPA)and carotid artery plaque in patients with acute cerebral infarction.Method 144 patients in Jiangsu Province Academy of Traditional Chinese Medicine were selected,86 patients in unstable carotid artery plaque group and 58 patients in stable carotid artery plaque group.Baseline data of patients were collected and LPA levels were measured.Results Compared with baseline data,there were no statistical differences in age,LDL,TG,TC,HDL,HbA1c,fibrinogen,platelet aggregation rate,carotid artery intima-media thickness,history of hypertension,diabetes or cerebral infarction,smoking and drinking(P>0.05);There were statistical differences in sex(P<0.05).LPA level in unstable plaque group was significantly higher than that in stable plaque group(P<0.05).Conclusion It is suggested that LPA level is correlated with the nature of carotid artery plaque in patients with acute cerebral infarction.