早期应用抗蛇毒血清中和游离毒素对南方毒蛇伤的应用效果

Early Application of Antivenom Serum to Neutralize Free Toxins for Southern Poisonous Snake Wounds

目的:探讨早期应用抗蛇毒血清中和游离毒素对南方毒蛇伤的应用效果。方法:纳入2018年5月-2019年5月笔者所在医院收治的80例毒蛇伤疾病患者,按照随机分组的方式分为两组,接受常规救治的设为对照组,接受早期应用抗蛇毒血清治疗的设为研究组,对比两组临床效果。结果:治疗前两组BUN、TB、TT、PT对比差异无统计学意义(P>0.05),治疗后两组BUN、TB、TT、PT均低于治疗前,且研究组各指标均低于对照组,差异均有统计学意义(P<0.05);研究组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。结论:南方毒蛇伤患者积极采取急救救治措施,同时早期应用抗蛇毒血清中和游离毒素,可促进毒素排出,防止肝肾功能损伤,值得在临床上进行推广。

Objective:To investigate the effect of early application of antivenin and free toxin on venomous snake injury in southern China.Method:A total of 80 patients with viper injury admitted to the author’s hospital from May 2018 to May 2019 were included.The patients were randomly divided into two groups,those who received routine treatment were set as the control group,and those who received early treatment with antivenom were set as the study group.The clinical effects of the two groups were compared.Result:Before treatment,there was no significant difference in BUN,TB,TT and PT between the two groups(P>0.05),after treatment,BUN,TB,TT and PT in the two groups were all lower than those before treatment,and all indexes in the study group were lower than those in the control group,the differences were statistically significant(P<0.05).The total effective rate of the treatment group was higher than that of the control group,the difference was statistically significant(P<0.05).Conclusion:The patients with venomous snake injury in southern China should actively take emergency treatment measures,and at the same time early use of antivenoms to neutralize free toxins,promote toxin excretion,and prevent liver and kidney function damage.The results of this study confirmed that it is worth promoting in clinical practice.