龙血竭对辐射诱导的神经炎症的保护作用

Dragon’s Blood Has Protective Effects in Irradiation-induced Neuroinflammation

深空探测的不断发展,潜在的战争威胁以及核事故的发生增加了人类辐射暴露的风险.神经炎症是人体在辐射暴露后重要生理反应之一.神经炎症的发生与神经退行性疾病如阿尔茨海默病(Alzheimer’s disease,AD)和帕金森病(Parkinson’s disease,PD)密切相关.开发具有抗氧化和抗炎作用的中药对辐射引起的中枢神经系统损伤有积极意义.中药龙血竭对辐射诱导的神经炎症具有良好的治疗作用.本文总结了龙血竭在降低氧化应激水平,相关炎症因子表达和线粒体损伤中的作用.同时提出,内源性神经毒素可能加重辐射诱导的神经炎症的进程,而龙血竭可缓解这种神经炎症.

The continuous development of deep space exploration,the potential threat of war,and the occurrence of nuclear accidents increase our exposure to irradiation.Irradiation-induced neuroinflammation is one of the important aspects.The occurrence of neuroinflammation is closely related to neurodegenerative diseases such as Alzheimer’s disease(AD)and Parkinson’s disease(PD).The development of traditional Chinese medicines(TCM)with antioxidant and anti-inflammatory effects has positive implications for irradiation-induced damage to the central nervous system(CNS).Traditional Chinese medicine dragon’s blood has a good effect on the treatment of radiation-induced neuroinflammation.This review summarizes the role of dragon’s blood in reducing oxidative stress levels,expression of related inflammatory factors,and mitochondrial damage.At the same time,we propose that endogenous neurotoxins may aggravate brain-induced neuroinflammation which might be alleviated by dragon’s blood.