制首乌颗粒治疗高脂血症临床研究

Clinical Study on Zhishouwu Granules for Hyperlipidemia

目的:观察制首乌颗粒治疗高脂血症的临床疗效。方法:将40例高脂血症患者随机分为对照组和观察组,每组20例。观察组使用制首乌颗粒联合瑞舒伐他汀钙片治疗,对照组仅给予瑞舒伐他汀钙片治疗。治疗后,评估2组临床疗效,比较2组治疗前后血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)及高密度脂蛋白胆固醇(HDL-C)水平,记录2组不良反应发生情况。结果:观察组总有效率为95.0%,对照组为85.0%。治疗14 d、28 d后,观察组TC、TG、LDL-C水平均较治疗前下降(P<0.05),且低于同期对照组(P<0.05);治疗28 d后,观察组HDL-C水平较治疗前升高(P<0.05),且高于同期对照组(P<0.05)。观察组不良反应发生率(15.0%)明显低于对照组(5.0%)(P<0.05)。结论:制首乌颗粒治疗高脂血症临床疗效良好,可明显改善血液中血脂成分异常情况。

Objective:To observe the clinical effect of Zhishouwu granules for hyperlipidemia.Methods:A total of 40 cases of patients with hyperlipidemia were randomly divided into the control group and the observation group,20 cases in each group.The observation group was treated with Zhishouwu granules combined with rosuvastatin calcium tablets,and the control group was treated with rosuvastatin calcium tablets.After treatment,the clinical effect in the two groups were evaluated.The levels of total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C)and high-density lipoprotein cholesterol(HDL-C)before and after treatment were compared between the two groups.The occurrence of adverse reactions in two groups was recorded.Results:The total effective rate was 95.0% in the observation group,and 85.0% in the control group.After treatment for 14 and 28 days,the levels of TC,TG and LDL-C in the observation group were decreased(P<0.05),and the above three levels were lower than those in the control group at the same period(P<0.05);after 28-day treatment,the level of HDL-C in the observation group was increased when compared with those before treatment(P<0.05),and higher than that in the control group at the same period(P<0.05).The incidence of adverse reactions in the observation group(15.0%)was significantly lower than that in the control group(5.0%)(P<0.05).Conclusion:Zhishouwu granules has good clinical effect in treating hyperlipidemia and can significantly improve the abnormal lipid constituents in the blood.