藏医脉泻疗法治疗类风湿关节炎临床研究

Clinical Study on Pulse-Diarrhea Therapy of Tibetan Medicine for Rheumatoid Arthritis

目的:观察藏医脉泻疗法治疗类风湿关节炎的疗效。方法:选取90例类风湿关节炎患者,随机分为治疗组和对照组各45例,治疗组采用藏医脉泻疗法治疗,对照组采用口服美洛昔康片治疗。治疗4周后,比较2组治疗前后主要症状体征及疼痛评分、血沉(ESR)、C-反应蛋白(CRP)、类风湿因子(RF)水平、不良反应情况及临床疗效。结果:治疗组总有效率为95.6%,优于对照组的82.2%,差异有统计学意义(P<0.05)。治疗4周后,2组关节的压痛数、关节肿胀数、晨僵时间、双手平均握力及疼痛评分均较治疗前改善(P<0.05);治疗组关节压痛数、关节肿胀数、晨僵时间、双手平均握力及疼痛评分改善情况均优于对照组(P<0.05)。治疗后,2组ESR、CRP、RF水平均较治疗前降低(P<0.05);治疗组ESR、CRP水平均低于对照组治疗后(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:藏医脉泻疗法治疗类风湿关节炎临床效果满意,能显著改善临床症状体征及ESR、CRP、RF水平,且患者耐受性较好。

Objective:To observe the therapeutic effect of the pulse-diarrhea therapy of tibetan medicine for rheumatoid arthritis.Methods:A total of 90 patients with rheumatoid arthritis were randomly divided into the treatment group and the control group,45 cases in each group.The treatment group was adopted the pulse-diarrhea therapy of tibetan medicine,and the control group was treated with oral administration of meloxicam tablets.After four weeks of treatment,the main signs and symptoms,pain scores,levels of erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),rheumatoid factor(RF)and adverse reactions as well as clinical effect in the two groups were compared before and after treatment.Results:The total effective rate was 95.6% in the treatment group,better than that of 82.2% in the control group,the difference being significant(P<0.05).After four weeks of treatment,the number of cases of joint tenderness,the number of cases of joint swelling,the time of morning stiffness,the average grip strength of both hands and the pain score in the two groups were all improved when compared with those before treatment(P<0.05),and the above indexes in the treatment group were better than those in the control group(P<0.05).After treatment,the levels of ESR,CRP and RF in the two groups were reduced(P<0.05),and the above levels in the treatment group were lower than those in the control group(P<0.05).There was no significant difference in the comparison of incidence of adverse reactions between the two groups(P>0.05).Conclusion:The pulse-diarrhea therapy of tibetan medicine has a satisfactory clinical effect in treating patients with rheumatoid arthritis and can significantly improve the clinical symptoms and signs as well as levels of ESR,CRP and RF,and the patients have a good tolerance.