痛泻安脾汤联合肠胃散贴敷治疗腹泻型肠易激综合征临床研究

Clinical Study on Tongxie Anpi Tang Combined with Changweisan Application for Irritable Bowel Syndrome with Diarrhea

目的:观察痛泻安脾汤联合肠胃散贴敷治疗腹泻型肠易激综合征临床疗效。方法:将118例腹泻型肠易激综合征患者按随机数字表法分为2组,对照组59例采用肠胃散贴敷治疗,观察组59例采用肠胃散贴敷联合痛泻安脾汤治疗。对比2组患者治疗前后神经肽Y(NPY)、5-羟色胺(5-HT)、血清γ-干扰素(IFN-γ)、汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)、中医证候积分。结果:2组治疗前NPY、5-HT、IFN-γ比较,差异无统计学意义(P>0.05);2组治疗后较前改善,观察组治疗后NPY、5-HT、IFN-γ低于对照组,差异有统计学意义(P<0.05)。2组治疗前HAMD、HAMA比较,差异无统计学意义(P>0.05);2组治疗后较前改善,观察组治疗后HAMD、HAMA低于对照组,差异有统计学意义(P<0.05)。2组治疗前各项中医证候积分比较,差异无统计学意义(P>0.05);2组治疗后较前改善,观察组治疗后中医证候积分低于对照组,差异有统计学意义(P<0.05)。结论:痛泻安脾汤联合肠胃散贴敷治疗腹泻型肠易激综合征临床疗效显著,可明显改善患者腹部不适,缓解疼痛,提高胃肠功能,抑制不良情绪。

Objective:To observe the clinical effect of Tongxie Anpi tang combined with Changweisan application for irritable bowel syndrome with diarrhea.Methods:A total of 118 cases of patients with irritable bowel syndrome with diarrhea were divided into two groups according to the random number table method,59 cases in each group.The control group was treated with Changweisan application,and the observation group was additionally treated with Tongxie Anpi tang based on the treatment of the control group.Before and after treatment,the levels of neuropeptide Y(NPY),5-hydroxytryptamine(5-HT)and Interferon-γ(IFN-γ)and the scores of Hamilton Depression Scale(HAMD),Hamilton Anxiety Scale(HAMA)and Chinese medicine syndromes in the two groups were compared.Results:Before treatment,there was no significant difference being found in the comparison of NPY,5-HT and IFN-γbetween the two groups(P>0.05).After treatment,the levels of NPY,5-HT and IFN-γin the two groups were improved when compared with those before treatment,and the levels in the observation group were lower than those in the control group,the difference being significant(P<0.05).Before treatment,there was no significant difference being found in the comparison of HAMD and HAMA between the two groups(P>0.05).After treatment,the scores of HAMD and HAMA in the two groups were improved when compared with those before treatment,and the scores in the observation group were lower than those in the control group,the difference being significant(P<0.05).Before treatment,there was no significant difference being found in the comparison of Chinese medicine syndrome scores between the two groups(P>0.05).After treatment,the Chinese medicine syndrome scores in the two groups were improved when compared with those before treatment,and the level in the observation group was lower than that in the control group,the difference being significant(P<0.05).Conclusion:Tongxie Anpi tang combined with Changweisan application for irritable bowel syndrome with diarrhea has significant clinical effect,which can effectively improve abdominal discomfort and gastrointestinal function,relieve pain and inhibit bad mood.