Treg与放射性肺损伤

Tregs and radiation-induced lung injury

放射性肺损伤(RILI)是胸部肿瘤放疗后常见的不良反应之一,在数月后往往发展成为放射性肺纤维化。近年来,研究者对RILI的发生发展机制开展了大量探索,其中调节性T细胞(Treg)在RILI进展中的免疫学机制尤其受到国内外学者的重视。本期重点号刊登了几篇Treg与RILI方面的文章,这些文章从Treg在肺组织内的数量改变和免疫调节机制等方面报道了Treg参与RILI发生发展的研究成果,为RILI的预防和治疗提供了重要的科学基础。

As one of the common side effects of radiotherapy for thoracic tumor,radiation induced lung injury(RILI)might develop into radiation-induced pulmonary fibrosis several months later.A lot of exploration on the mechanisms of the occurrence and development of RILI was carried out in recent years.The immunological mechanisms of regulatory T cells(Tregs)in the progress of RILI have been paid more attention by domestic and foreign scholars.The key topic of the present issue published several articles on Tregs and RILI.These articles reported the results of Tregs involved in the occurrence and development of RILI from the aspects of the changes in the number of Tregs in lung tissue and immunological mechanisms,and which provided important scientific basis for the prevention and treatment of RILI.