早期预测急性胰腺炎严重程度的血清标志物概况及展望

Overview and prospect of serum markers for early prediction of severity of acute pancreatitis

急性胰腺炎(acute pancreatitis, AP)是消化系统最常见且具有潜在致命性的急症之一.胰酶的自身消化引起的胰腺无菌性炎症被认为是目前AP最主要的发病机制.不同严重程度的AP其临床病程及预后有较大的差异,因此早期预测AP的严重程度对该病的诊治意义重大.近年来,血清标志物用于AP患者的早期风险评估和严重程度分层的相关研究取得了很大进展.本文就早期预测AP严重程度的血清标志物概况及展望进行综述.

Acute pancreatitis(AP) is one of the most common and potentially fatal emergencies of the digestive system.Aseptic inflammation of the pancreas caused by selfdigestion of trypsin is considered to be the main pathogenesis of AP.The clinical course and prognosis of AP with different degrees of severity vary greatly,so early prediction of the severity of AP is of great significance to the diagnosis and treatment of this disease.In recent years,great progress has been made in the early risk assessment and severity stratification of AP patients with serum markers.This article gives an overview and discuss the prospects of serum markers for early prediction of the severity of AP.