热休克蛋白5与炎症性肠病研究进展

Heat shock protein 5 and inflammatory bowel disease

炎症性肠病(inflammatory bowel disease, IBD)是一种慢性复发性肠道炎症性疾病,黏膜屏障的完整性影响疾病的发生发展,肠上皮细胞作为黏膜屏障的主要构成包括Paneth细胞、杯状细胞等.热休克蛋白5是一种内质网应激的关键因子,主要通过内质网应激途径对肠上皮细胞的存活及凋亡产生影响,进而参与IBD的进程.

Inflammatory bowel disease is a kind of chronic recurrent intestinal inflammatory disease whose occurrence and development are affected by the integrity of the mucosal barrier.As the main component of the mucosal barrier,intestinal epithelial cells mainly include Paneth cells,goblet cells,etc.Heat shock protein 5 is a key factor for endoplasmic reticulum stress,and it affects the survival and apoptosis of intestinal epithelial cells mainly through endoplasmic reticulum stress pathways,and then participates in the process of inflammatory bowel disease.