摘要
猪对脱氧雪腐镰刀菌烯醇(DON)的敏感性明显高于其他动物,其肠道是接触和吸收DON的主要场所。仔猪由于肠道发育尚未完善,容易受到DON污染引起肠道上皮细胞凋亡,促使肠道自由基和促炎性细胞因子分泌增加,破坏紧密连接蛋白,导致肠道形态结构和屏障功能损伤,打破肠道微生物区系平衡,从而影响仔猪肠道健康和正常生长。本文将围绕肠道形态结构、肠道屏障、肠道微生物、肠道黏膜免疫和肠道氧化应激等方面对近年来有关DON影响仔猪肠道健康的研究进行综述,以期为饲料中DON污染的防治措施以及仔猪肠道健康的营养调控提供科学依据。
The sensitivity of pig to deoxynivalenol(DON) is significantly higher than that of other animals. The intestine is the main site to contact and absorb DON for pigs. Piglets are susceptible to DON contaminated feeds due to the immature intestinal development. DON can induce apoptosis of intestinal epithelial cells, increase the secretion of intestinal free radicals and inflammatory cytokines, destruct tight junction proteins, cause intestinal morphology damage and barrier dysfunction, thus affecting the intestinal health and normal growth of piglets. This review therefore will summarize the recent progress regarding on the effects of DON on intestinal health in piglets, including the changes of intestinal morphology, intestinal barrier, intestinal microbiota, intestinal mucosal immunity, and intestinal oxidative stress, aiming to provide scientific basis for the prevention and control of DON contaminations in feed as well as the nutritional regulation strategies of intestinal health in piglets.
作者
朱翠
白银山
蒋宗勇
王丽
ZHU Cui;BAI Yinshan;JIANG Zongyong;WANG Li(School of Life Science and Engineering,Foshan University,Guangdong Foshan 528225,China;Key Laboratory of Animal Nutrition and Feed(South China)of Ministry of Agriculture and Rural Developement,Guangdong Public Laboratory of Animal Breeding and Nutrition,Institute of Animal Science,Guangdong Academy of Agricultural Sciences,Guangdong Guangzhou 510640,China)
出处
《中国畜牧杂志》
CAS
北大核心
2020年第8期21-25,共5页
Chinese Journal of Animal Science
基金
广东省普通高校特色创新类项目(2018KTSCX244)
十三五国家重点研发计划(2018YFD0501101)
国家生猪产业技术体系建设专项(CARS-35)
广东省基础与应用基础研究基金(2020A1515010018)。
