耐受性树突状细胞的研究进展

Research Progress on Tolerogenic Dendritic Cells

耐受性树突状细胞(tolerogenic dendritic cell, tolDC)在器官移植和自体免疫性疾病中对免疫耐受调节至关重要。与免疫抑制剂相比, tolDC用于治疗移植后排斥反应的副作用较低。此外, tolDC可通过多种途径培养生成,且不同的培养方式具有独特功效。目前, tolDC作为一种诱导器官移植耐受的辅助治疗已在临床试验中广泛应用。本文就tolDC诱导免疫耐受、tolDC的体外诱导培养及其mi RNA调控机制和应用进行综述并提出相关展望,以期为应用tolDC治疗减轻移植后排斥反应的研究提供新思路。

Tolerogenic dendritic cells(tolDCs) are critical for regulation of immune tolerance in organ transplantation and autoimmune diseases. Compared with immunosuppressants, the side effects of tolDCs for treatment after transplantation are fewer. In addition, tolDCs can be cultivated by a variety of ways and different culture methods have different efficacies. At present, tolDCs have been widely used in clinical trials as an adjuvant therapy to induce organ transplant tolerance. Herein, the immune tolerance induced by tolDCs,culture methods of tolDCs in vitro, miRNAs regulatory mechanism and application of tolDCs were reviewed,and related research prospects were put forward, with the hope of providing guidance for tolDCs therapy to reduce transplantation rejection.