热休克蛋白在脊髓损伤中的研究进展

Research Progresses of Heat Shock Proteins in Spinal Cord Injury

脊髓损伤(spinal cord injury, SCI)可造成损伤平面以下神经功能障碍,严重影响患者的生活质量。热休克蛋白(heat shock proteins, HSPs)是机体受到应激后保护细胞或组织,使其免受进一步伤害的重要分子之一,在脊髓损伤后表达升高,并通过促进血管生成、抑制炎症反应、抑制神经元凋亡、抗氧化应激等作用减缓脊髓损伤的进一步加重。本文主要就脊髓损伤后热休克蛋白的产生及其作用机制的研究进展进行综述,为后续相关研究提供参考。

Spinal cord injury(SCI) can cause neurological dysfunction below the injury level, which seriously affects the patient’s quality of life. Heat shock proteins(HSPs) are one kind of the important molecules that protect cells or tissues from further injury after stress in the body. The expression of HSPs is increased after spinal cord injury, and the proteins can slow down further aggravation of spinal cord injury by promoting angiogenesis and inhibiting inflammatory response, neuron apoptosis and oxidative stress. Herein, the production and function mechanisms of HSPs after spinal cord injury are reviewed to provide reference for the related research in the future.