中西医结合治疗视网膜静脉阻塞继发黄斑水肿的Meta分析

Meta-analysis of traditional Chinese medicine and western medicine in treating retinal vein occlusion complicated by macular edema

目的:通过Meta分析评价中西医结合治疗视网膜静脉阻塞(RVO)继发黄斑水肿(ME)的临床疗效。方法:通过检索中国知网、万方、PubMed、Cochrane Library等数据库,收集所有中西医结合治疗RVO继发ME的随机对照试验(RCTs),采用Revman5.3软件进行Meta分析。结果:一共纳入30篇文献,共包括1943例患者,1976只眼。Meta分析结果显示:与单纯西医治疗相比,中西医结合治疗RVO继发ME能明显提高最佳矫正视力[(MD=0.08,95%CI=0.07~0.10,P<0.00001)、(MD=-0.16,95%CI=-0.24^-0.08,P=0.0002)、(MD=5.78,95%CI=1.30~10.25,P=0.01)],减少黄斑中心凹厚度(MD=-54.6,95%CI=-73.76^-35.43,P<0.00001),提高临床疗效(RR=1.32,95%CI=1.22~1.43,P<0.00001)。结论:中西医结合治疗RVO继发ME在提高最佳矫正视力、减轻黄斑中心凹厚度、提高临床疗效方面优于单纯西医治疗组。

Objective To evaluate the clinical efficacy of the combination of traditional Chinese medicine and western medicine in treating patients with retinal vein occlusion(RVO)complicated by macular edema(ME).MethodsThe CNKI,Wanfang Data,PubMed and Cochrane Library from database were searched.All of randomized controlled trials(RCTs)of the combination of traditional Chinese medicine and western medicine in treating patients with RVO complicated by ME were searched.The Revman5.3 software were used for meta-analysis.Results A total of 30 trials involving 1943 patients and 1976 eyes were included.Meta-analysis showed that compared with western medicine,the combination of traditional Chinese medicine and western medicine can significantly improve the best corrected visual acuity(MD=0.08,95%CI=0.07-0.10,P<0.00001)(MD=-0.16,95%CI=-0.24-0.08,P=0.0002)(MD=5.78,95%CI=1.30-10.25,P=0.01),reduce the central macular thickness(MD=-54.6,95%CI=-73.76-35.43,P<0.00001),and improve the clinical effective rate(RR=1.32,95%CI=1.22-1.43,P<0.00001).Conclusions The combination of traditional Chinese and western medicine in treating patients with RVO complicated by ME was superior to western medicine in improving the best corrected visual acuity,reducing the thickness of macular fovea and improving the clinical efficacy.