摘要
正常的妊娠过程依赖于羊水中一系列复杂的蛋白相互作用保持相对的平衡,当胎儿生长发育出现异常时,羊水蛋白质组将会发生改变。近年来,羊水蛋白质组技术被广泛应用于筛选胎儿染色体异常早期标志物的研究,本综述关注胎儿染色体异常时羊水蛋白质组学的研究进展,这将有助于阐明胎儿染色体异常的病理生理变化,从而有望发现新的产前筛查标志物。
Normal pregnancy depends on a series of complex protein interactions in amniotic fluid to maintain relative balance.When the fetal growth and development is abnormal,the amniotic fluid proteome will change.In recent years,amniotic fluid proteome technique has been widely used to screen early markers of fetal chromosome abnormalities.This review aims at focusing on the advances in the study of amniotic fluid proteomics in cases of fetal chromosome abnormalities.This will help to clarify the patho-physiological changes of fetal chromosome abnormalities,and it is expected to find new markers for prenatal screening.
作者
岑姣
周熙颖
吕莉琴
庞丽红
Cen Jiao;Zhou Xiying;Lv Liqin;Pang Lihong(Department of Prenatal Diagnosis and Genetic Diseases,The First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China)
出处
《广西医科大学学报》
CAS
2020年第8期1570-1576,共7页
Journal of Guangxi Medical University
基金
广西自然科学基金资助项目(No.2014GXNFA118248)
国家自然科学基金资助项目(No.81660256)。
关键词
羊水
蛋白组质学
胎儿染色体异常
产前筛查标志物
amniotic fluid
proteomics
fetal chromosome abnormalities
prenatal screening markers