摘要
背景与目的:化疗是晚期食管癌患者的主要治疗手段,但目前尚没有标准的一线治疗方案,通过白蛋白结合型紫杉醇联合奈达铂方案治疗晚期食管癌,评价其临床疗效及安全性。方法:收集2016年2月—2019年2月之间在长海医院诊治的晚期食管癌并有可评价病灶的患者31例,一线予以白蛋白结合型紫杉醇联合奈达铂方案化疗,具体用药为:白蛋白结合型紫杉醇130 mg/m^2,第1、8天;奈达铂70 mg/m^2,第1天;每3周重复。采用实体瘤疗效评价标准(Response Evaluation Criteria in Solid Tumors,RECIST)1.1标准评估疗效,按照美国国立癌症研究所通用毒性标准(National Cancer Institute Common Toxicity Criteria,NCI-CTC)5.0评估不良反应。结果:全部31例患者均可评价疗效,其中完全缓解(complete response,CR)1例(3.2%),部分缓解(partial response,PR)20例(64.5%),疾病稳定(stable disease,SD)9例(29.0%),疾病进展(progressive disease,PD)1例(3.2%),客观缓解率(objective response rate,ORR)为67.7%,疾病控制率(disease control rate,DCR)为96.8%,中位无进展生存期(progression-free survival,PFS)为9.4个月。常见不良反应主要包括骨髓抑制、感觉神经病变、关节酸痛、肌肉酸痛、消化道反应及脱发,无毒性相关死亡病例。结论:白蛋白结合型紫杉醇联合奈达铂一线治疗晚期食管癌疗效较好,不良反应患者可耐受,值得进一步推广。
Background and purpose:Chemotherapy remains the main treatment method for metastatic esophageal squamous cell carcinoma(ESCC).However,no standard regimen has been established as first-line therapy for metastatic ESCC.The purpose of this study was to observe the clinical efficacy and safety of albumin-bound paclitaxel plus nedaplatin as first-line therapy in patients with metastatic ESCC.Methods:Clinical outcomes of 31 patients with metastatic ESCC in Changhai Hospital between Feb.2016 and Feb.2019 were analyzed.These patients received albumin-bound paclitaxel combined with nedaplatin as first-line therapy.Albumin-bound paclitaxel was administered at a dose of 130 mg/m^2 on day 1 and 8 of a 21-day cycle.Nedaplatin was administered at a dose of 70 mg/m^2 on day 1 of a 21-day cycle.Evaluation of tumor response was performed according to Response Evaluation Criteria in Solid Tumors 1.1(RECIST 1.1).Toxicities were graded using version of the National Cancer Institute Common Toxicity Criteria(NCI-CTC)5.0.Results:All patients were available for evaluation.Of the 31 patients,1 case(3.2%)got complete response(CR),20 cases(64.5%)got partial response(PR),9 cases(29.0%)had stable disease(SD)and 1 case(3.2%)had progressive disease(PD).The objective response rate(ORR)was 67.7%,the disease control rate(DCR)was 96.8%and the median progressionfree survival(PFS)was 9.4 months.The main toxicities included hematological toxicity,sensory neuropathy,arthralgia,myalgia,gastrointestinal reactions and alopecia.Conclusion:The combination of albumin-bound paclitaxel and nedaplatin is found to be an effective and tolerable option as first-line therapy for patients with metastatic ESCC.
作者
颜芳
应明真
陈龙佩
傅强
YAN Fang;YING Mingzhen;CHEN Longpei;FU Qiang(Department of Oncology,Changhai Hospital,Shanghai 200433,China)
出处
《中国癌症杂志》
CAS
CSCD
北大核心
2020年第8期632-635,共4页
China Oncology
关键词
食管癌
白蛋白结合型紫杉醇
奈达铂
化学治疗
Esophageal squamous cell carcinoma
Albumin-bound paclitaxel
Nedaplatin
Chemotherapy