可见光催化环丁醇的C-C断裂胺化反应的研究

Visible Light Induced C-C Bond Cleavage and Amination Reaction of Cyclobutanols

报道了一种可见光诱导的铈催化的四元环醇的开环胺化反应。该方法利用可见光为光源,廉价的三氯化铈为光催化剂,利用配体到金属的电荷转移过程产生烷氧自由基,再经β裂解并被偶氮类化合物捕捉,合成一系列六氢哒嗪含氮化合物。该反应结合可见光和廉价的铈盐,开发了一种通用的对酮的选择性C-C裂解和官能团化的实用策略。该方法操作简单,普通的环丁酮类化合物可以成功转化为通用的化学结构单元。该方法提供含氮化合物的同时丰富了C-C断裂转化。

A visible⁃light induced strategy for C-C bond cleavage,amination of cyclobutanols was reported.The key alkoxy radicals were generated by employing inexpensive cerium catalyst,though charge transfer under visible⁃light irradiation which would undergo a selectiveβ⁃scission and trapped by DBAD to afford hexahydropyridazine derivatives effectively.This reaction combines visible light and inexpensive cerium salts to develop a general practical strategy for the selective carbon⁃carbon bond cleavage and functionalization of ketones.Under operationally simple conditions,cyclobutanone compounds can be successfully converted into universal chemical structural units.Provides a nitrogen⁃containing compound while enriching the carbon⁃carbon bond breaking conversion method.