光谷济生方治疗恢复期新型冠状病毒肺炎的临床效果

Clinical effect of Guanggu Jisheng decoction in treatment of recovery stage coronavirus disease 2019

目的观察光谷济生方治疗恢复期新型冠状病毒肺炎(COVID-19)的临床效果。方法对湖北省妇幼保健院光谷院区122例恢复期COVID-19患者用光谷济生方进行治疗(3 d为1个疗程,共3个疗程),比较服药前后患者中医证候的变化。根据实验室指标及症状严重程度(无、轻、中、重)给予相应评分,评价光谷济生方治疗恢复期COVID-19的临床效果。结果统计分析中医证候评分,治疗3 d总有效率为75.41%(92/122),其中有效31.97%(39/122)、显效21.31%(26/122)、临床痊愈22.13%(27/122);治疗6 d总有效率为86.89%(106/122),其中有效32.79%(40/122)、显效28.69%(35/122)、临床痊愈25.41%(31/122);治疗9 d总有效率为88.52%(108/122),其中有效16.39%(20/122)、显效31.15%(38/122)、临床痊愈40.98%(50/122)。患者的咳嗽、乏力、气短、虚汗症状明显改善,无一例患者呼吸道病原体核酸阴性转阳性。结论光谷济生方治疗恢复期COVID-19有较好的临床效果,能明显改善患者的临床症状。

Objective To observe the clinical effect of Guanggu Jisheng decoction on the treatment of coronavirus disease 2019(COVID-19)during recovery stage.Methods A total of 122 convalescent COVID-19 patients in Guanggu Branch of Maternity and Child Healthcare Hospital of Hubei Province were treated with Guanggu Jisheng decoction for 3 consecutive courses,each course lasting 3 days.The changes of traditional Chinese medicine(TCM)syndromes before and after treatment were compared.Scores were recorded according to the laboratory testing and the severity of symptoms(no symptom,mild,common and severe)to investigate the clinical curative effect of Guanggu Jisheng decoction on the treatment of convalescent COVID-19.Results According to the TCM syndrome scores,after one course of treatment(3 days),the total effective rate was 75.41%(92/122),with the effective rate being 31.97%(39/122),the significant efficiency being 21.31%(26/122),and the clinical recovery rate being 22.13%(27/122).After two courses of treatment(6 days),the total effective rate was 86.89%(106/122),with the effective rate being 32.79%(40/122),the significant efficiency being 28.69%(35/122),and the clinical recovery rate being 25.41%(31/122).After three courses of treatment(9 days),the total effective rate was 88.52%(108/122),with the effective rate being 16.39%(20/122),the significant efficiency being 31.15%(38/122),and the clinical recovery rate being 40.98%(50/122).The symptoms of cough,fatigue,shortness of breath and sweating were significantly improved.No patients turned positive again from negative of respiratory pathogen nucleic acid.Conclusion Guanggu Jisheng decoction has a good clinical effect on convalescent COVID-19 patients.It can significantly improve the clinical symptoms.