基质金属蛋白酶在脑血管疾病中的研究进展

Research progress of matrix metalloproteinases in cerebrovascular diseases

脑血管疾病如颅内动脉粥样硬化、颅内动脉瘤、缺血性脑卒中等已成为人类致死、致残的重要原因,在多种致病因素共同作用下脑血管结构和功能改变是脑血管疾病共同的病理生理基础。目前,脑血管疾病的病因尚未得到阐明,有越来越多的证据表明基质金属蛋白酶在其发生、发展中发挥重要作用,阻断或抑制基质金属蛋白酶的表达为脑血管疾病的无创治疗提供了新理论依据。本文综述基质金属蛋白酶与脑血管疾病的相关关系。

Cerebrovascular diseases such as intracranial atherosclerosis,intracranial aneurysm and ischemic stroke have become the important causes of death and disability.The structural and functional changes of cerebrovascular,which are caused by various pathogenic factors,are the common pathophysiological basis of cerebrovascular diseases.At present,the etiology of cerebrovascular diseases has not been clarified.Growing evidence suggests that matrix metalloproteinases play an important role in the occurrence and development of cerebrovascular diseases.Blocking or inhibiting the expression of matrix metalloproteinases provides a new theoretical basis for non-invasive treatment of cerebrovascular diseases.This review discusses the relationship between matrix metalloproteinases and cerebrovascular diseases.