摘要
随着人们生活方式和环境因素的变化,癌症的发病率呈不断上升之势。二茂铁类化合物具有廉价、稳定、亲脂、强氧化还原和低毒等特性,显示出良好的抗肿瘤活性。其中,二茂铁-酚杂合体Ferrocifen对包括耐药肿瘤细胞系在内的多种肿瘤细胞系具有显著地抑制作用。当前,此类化合物正处于临床前研究阶段,有希望在不久的将来为人类健康服务。显然,二茂铁杂合体在抗肿瘤领域有着广泛的应用前景。本文将对近年来二茂铁杂合体在抗肿瘤领域中的研究进展作出概述,以求为药物化学家进一步设计活性更高的杂合体提供参考。
The morbidity of cancer continues to grow due to the change of lifestyle and environment.Ferrocene derivatives which endow with many advantages such as low cost,stability,high lipotropy,strong redox,and low toxicity,exhibit potential anticancer activity.Among them,ferrocene-phenol hybrid Ferrocifen which possess excellent activity against various cancer cell lines including drug-resistant cells,is in pre-clinical trial,demonstrating the anticancer potential of ferrocene hybrids.This review will summarize the recent development of ferrocene hybrids as potential anticancer leads to pave the way for the further design of novel hybrids with higher activity.
作者
宋旭锋
孙志成
Song Xu-feng;Sun Zhi-cheng(Beijing Key Laboratory for Green Catalysis and Separation,Department of Chemistry and Chemical Engineering,College of Environmental and Energy Engineering,Beijing University of Technology,Beijing 100124;Bering Institute of Graphic Communication,Beijing Engineering Research Center of Printed Electronics,Beijing 102600)
出处
《国外医药（抗生素分册）》
CAS
2020年第3期170-178,共9页
World Notes on Antibiotics
基金
微囊化卟啉/石墨烯非共价复合染料的可控制备及构效调控(国家自然科学基金,21776021)。
关键词
二茂铁
杂化物
抗癌
耐药性
构-效关系
ferrocene
hybrids
anticancer
drug resistance
structure-activity relationship
