法洛四联症胎儿脑血流动力学的变化

Clinical study of cerebral hemodynamic changes in fetuses with tetralogy of fallot

目的探讨法洛四联症胎儿脑血流动力学的改变。方法选择2016年6月至2019年8月安徽医科大学附属安庆医院经超声心动图诊断为法洛四联症胎儿20例为观察组,选取同期孕周匹配的25例正常胎儿为对照组。测量两组胎儿双顶径、头围,并利用频谱多普勒超声技术测量胎儿大脑中动脉搏动指数(MCA-PI)、脐动脉搏动指数(UA-PI)及计算脑脐动脉搏动指数比值(CPR),比较两组胎儿双顶径、头围、MCA-PI、UA-PI及CPR有无差别。结果观察组胎儿MCA-PI和CPR与对照组相比减低,差异具有统计学意义(t=-2.933、-2.503,P<0.05);观察组胎儿UA-PI与对照组相比,差异无统计学意义(t=-0.296,P>0.05)。结论法洛四联症胎儿脑血流动力学有一定的改变。

Objective To explore the changes in the cerebral hemodynamics in fetuses with tetralogy of fallot(TOF).Methods Twenty fetuses with TOF diagnosed by fetal echocardiography in Anqing affiliated hospital of Anhui medical university from June 2016 to August 2019 were selected as observation group,and 25 normal fetuses were selected as control group.The biparietal diameter(BPD)and head circumference(HC)in two groups were measured,the pulsatility index of middle cerebral artery(MCA-PI)and umbilical artery(UA-PI)were measured by pulsed Doppler ultrasound technique.The cerebroplacental ratio(CPR)was calculated by MCA-PI/UA-PI.The BPD,HC,MCA-PI,UA-PI and CPR were compared between two groups.Results MCA-PI and CPR in observation group were significantly lower than those in control group(t=-2.933,-2.503,P<0.05).There was no significant difference of UA-PI between the observation group and control group(t=-0.296,P>0.05).Conclusion There are some changes in the cerebral hemodynamics in fetuses with TOF.