抗apoA-1 IgG、MMP9、Cys-C与脑梗死患者颈动脉厚度的关系

The relationship between anti-apolipoprotein A1 antibody immunoglobulin G,matrix metalloproteinase 9,cystatin C and carotid intima-media thickness in patients with acute cerebral infarction

目的探讨急性脑梗死(ACI)患者血清抗载脂蛋白A1抗体(抗apoA-1 IgG)、基质金属蛋白酶9(MMP9)、胱抑素C(Cys-C)水平的变化与患者颈动脉内-中膜厚度(IMT)的关系。方法选取2015年3月至2018年3月浙江省安吉县人民医院确诊的ACI患者120例作为ACI组,选取120例健康体检对象作为对照组,检测对比两组的血清抗apoA-1 IgG、MMP9、Cys-C水平,并按照患者颈动脉斑块性质进行分组分析,采用线性相关分析法探讨血清抗apoA-1 IgG、MMP9、Cys-C水平与IMT的相关性。结果ACI组患者的抗apoA-1 IgG、MMP9、Cys-C水平与IMT测定值均显著的高于对照组,差异均具有统计学意义(t=13.172、25.285、11.774、14.001,P<0.01);易损斑块的ACI组患者的抗apoA-1 IgG、MMP9、Cys-C水平均显著的高于稳定性斑块组和无斑块组患者,差异均具有统计学意义(F=27.337、17.483、21.846,P<0.01);稳定性斑块组的ACI组患者的抗apoA-1 IgG、MMP9、Cys-C水平均显著的高于无斑块组患者,差异均具有统计学意义(P<0.01);ACI组患者的抗apoA-1 IgG、MMP9、Cys-C水平与患者IMT测定值均呈显著的正相关(r=0.418、0.603、0.590,P<0.01)。结论ACI患者血清抗apoA-1 IgG、MMP9、Cys-C水平显著升高,可能与颈动脉粥样硬化有一定的关系。

Objective To investigate the relationship between serum levels of antiapolipoprotein A1 antibody immunoglobulin G(anti-apoA-1 IgG),matrix metalloproteinase 9(MMP9),cystatin C(Cys-C)and carotid intima-media thickness(IMT)in patients with acute cerebral infarction(ACI).Methods 120 patients with ACI diagnosed in Anji county people's hospital from March 2015 to March 2018 were selected as ACI group,and 120 healthy subjects were selected as the control group.Serum levels of anti-apoA-1 IgG,MMP9,Cys-C were compared between the two groups,and grouped according to the nature of carotid plaque.The correlation between serum levels of anti-apoA-1 IgG,MMP9,Cys-C and IMT was investigated by linear correlation analysis.Results The levels of antiapoA-1 IgG,MMP9,Cys-C and IMT in the ACI group were significantly higher than those in the control group,and the difference was statistically significant(t=13.172,25.285,11.774,14.001,P<0.01).The levels of anti-apoA-1 IgG,MMP9,and Cys-C in patients with vulnerable plaque in ACI group were significantly higher than those in stable plaque group and plaque-free group(F=27.337,17.483,21.846,P<0.01).The levels of anti-apoA-1 IgG,MMP9,and Cys-C in the ACI group of the stable plaque group were significantly higher than those in the non-plaque group,and the differences were statistically significant(P<0.01).The levels of anti-apoA-1 IgG,MMP9,Cys-C in the ACI group were significantly positively correlated with the IMT measured values(r=0.418,0.603,0.590,P<0.01).Conclusion The serum levels of anti-apoA-1 IgG,MMP9 and Cys-C in ACI patients are significantly increased,which may be related to carotid atherosclerosis.