半乳糖凝集素3与乳腺癌的研究进展

Research progress of galectin-3 and breast cancer

半乳糖凝集素3(Gal-3)是糖粘合蛋白家族的一员,在多种肿瘤的发生、进展、侵袭和转移中起重要作用。Gal-3的过表达增强了肿瘤细胞的活性、侵袭性,并且抑制细胞的凋亡,促进血管生成并诱导肿瘤免疫逃逸。文章主要就乳腺癌诊断、预后、治疗、转移等方面对Gal-3与乳腺癌相关性进行综述。

Galectin-3 is a member of glycobinding protein family,which plays an important role in the tumor occurrence,progression,invasion and metastasis.The overexpression of galectin-3 enhances the activity and invasiveness of cancer cells,and inhibits the apoptosis of breast cancer cells.Also,it promotes angiogenesis and induces tumor immune escape.In this paper,we discuss the relationship between galectin-3 and breast cancer in diagnosis,prognosis,treatment and metastasis of breast cancer.