红花注射液联合肢体康复疗法治疗脑梗死患者的疗效及对血清炎症因子的影响

Effect of Safflower Injection Combined with Limb Rehabilitation Therapy in the Treatment of Cerebral Infarction and its Influence on Serum Inflammatory Factors

【目的】探讨红花注射液联合肢体康复疗法治疗脑梗死患者的疗效及对血清炎症因子的影响。【方法】选取2015年9月至2017年5月在本院在诊治的脑梗死患者112例,按照随机数表法分为观察组和对照组,对照组给予常规康复治疗,观察组在对照组基础上加用红花注射液治疗;比较两组患者临床疗效、血流动力学变化、血清炎症因子水平。【结果】观察组临床总有效率为92.86%,明显高于对照组的78.57%,差异具有统计学意义(χ^2=4.667,P<0.05);治疗后,观察组Fugl-Meyer评定量表(FMA)评分、Barthel指数(BI)评分明显高于对照组,美国国立卫生院卒中量表(NIHSS)评分明显低于对照组,其差异具有统计学意义(P<0.05);观察组全血高切黏度、低切黏度、血浆黏度明显低于对照组,双侧大脑中动脉血流最大峰值流速、血管阻力指数明显高于对照组,其差异具有统计学意义(P<0.05);治疗后,观察组血清超敏C反应蛋白(hs-CRP)、中枢神经特异蛋白(S100β蛋白)水平明显低于对照组,血管内皮生长因子(VEGF)、转化生长因子-β1(TGF-β1)水平明显高于对照组,差异具有统计学意义(P<0.05);两组患者不良反应发生率比较差异无统计学意义(P>0.05)。【结论】在常规康复治疗基础上辅以红花注射液能够有效提高脑梗死患者临床疗效,改善患者血流状态,降低血清炎症因子水平,值得临床推广应用。

【Objective】To investigate the curative effect of safflower injection combined with limb rehabilitation therapy in the treatment of cerebral infarction and its influence on serum inflammatory factors.【Methods】One hundred and twelve patients with cerebral infarction in our hospital from September 2015 to may 2017 were selected and randomly divided into observation group and control group.The control group was given routine rehabilitation treatment,while the observation group was treated with Safflower Injection on the basis of the control group.The clinical efficacy,hemodynamic changes and serum inflammatory factor levels of the two groups were compared.【Results】The clinical total effective rate of the observation group was 92.86%,significantly higher than 78.57%of the control group,the difference was statistically significant(χ^2=4.667,P<0.05);after treatment,the Fugl Meyer Rating Scale(FMA)score and Barthel Index(BI)score of the observation group were significantly higher than those of the control group,and the NIHSS score was significantly lower than that of the control group(P<0.05)The blood high shear viscosity,low shear viscosity and plasma viscosity of the observation group were significantly lower than those of the control group,and the maximum peak flow velocity and vascular resistance index of bilateral middle cerebral arteries were significantly higher than those of the control group,and the difference was statistically significant(P<0.05);after treatment,the levels of serum high-sensitivity C-reactive protein(hs CRP)and central nerve specific protein(S100βprotein)in the observation group were significantly lower than those in the control group The levels of vascular endothelial growth factor(VEGF)and transforming growth factor-β1(TGF-β1)in the two groups were significantly higher than those in the control group(P<0.05);there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).【Conclusion】On the basis of conventional rehabilitation therapy,safflower injection can effectively improve the clinical efficacy of patients with cerebral infarction,improve the blood flow status of patients,and reduce the level of serum inflammatory factors,which is worthy of clinical application.