成年突聋患者血清HIF-α、VEGF的表达与临床意义

Serum Levels and Clinical Significance of HIF-αand VEGF in Adult Patients with Sudden Sensorineural Hearing Loss

【目的】探讨成年突发性聋(SSHL)患者血清缺氧诱导因子-α(HIF-α)和血管内皮生长因子(VEGF)的表达水平与临床意义。【方法】本院收治的50例成年SSHL患者为观察组,选择同期于本院健康体检的健康志愿者50例为对照组,检测比较两组血清HIF-α和VEGF水平,并分析两者与SSHL的相关性。【结果】观察组血清HIF-α水平显著高于对照组,且差异具有显著性(P<0.05);观察组血清VEGF水平高于对照组,但两组比较差异无显著性(P>0.05);年龄小于或等于40岁的SSHL患者血清VEGF水平显著高于年龄大于40岁者(P<0.05);不同年龄的SSHL患者血清HIF-α水平比较差异无显著性(P<0.05);不同性别、耳聋程度的SSHL患者血清HIF-α和VEGF水平比较差异均无显著性(P<0.05)。【结论】SSHL患者血清HIF-α、VEGF水平变化与SSHL的发病机制相关,这种变化及相关性对于提示疾病严重程度、指导临床治疗及评估预后水平有一定的指导意义。

【Objective】To investigate the clinical significance through measuring serum levels of hypoxia-inducing factor-α(HIF-α)and vascular endothelial growth factor(VEGF)in adult patients with sudden sensorineural hearing loss(SSHL).【Method】Clinical data of 50 adult patients with SSHL admitted to our hospital were selected as the observation group,and 50 healthy volunteers who underwent physical examination in our hospital during the same period were selected as the control group.Serum HIF-αand VEGF levels in the two groups were detected,then their correlation to SSHL was analyzed.【Result】The level of HIF-αin the observation group was significantly higher than that in the control group(P<0.05).In the observation group,there was no significant difference in the HIF-αlevel among SSHL patients of different ages(P>0.05);The level of VEGF in the observation group was not significantly higher than that in the control group(P>0.05).However,the VEGF level of SSHL patients aged less than or equal to 40 years old was significantly higher than that of patients aged over 40 years old(P<0.05).There were no significant differences in the levels of HIF-αand VEGF in SSHL patients with different genders and deafness degrees(P<0.05).【Conclusion】The changes of serum HIF-αand VEGF levels in SSHL patients are related to the pathogenesis of SSHL.These changes and correlations may indicate the severity of the disease,help clinical treatment and evaluate the prognosis.