微生物脂肽的疫苗学应用及进展

Application and progress of microbial lipopeptides in vaccine science

微生物脂肽是近几年研究的热点之一。天然微生物脂肽是由微生物产生的次级代谢产物,合成微生物脂肽则是在天然微生物脂肽的结构基础上进行结构修饰获得。现有研究表明,微生物脂肽具有显著的疫苗或佐剂活性,并且能发挥抗菌、抗病毒、抗肿瘤、抗黏附等作用,具有广阔的应用前景。本文通过对几种微生物脂肽的结构和功能进行简要总结,概述脂肽在疫苗领域的应用,为新疫苗和佐剂的设计提供借鉴。

Lipopeptides is one of the hot spot of research in recent years.Natural lipopeptides are the secondary metabolites produced by prokaryotes,while synthetic lipopeptides is based on the natural lipopeptide’s structure and retains the core structure with modified active group.Recent studies have shown that lipopeptides has significant vaccine/adjuvant activity,and have the ability of antibacterial,antivirus,antitumor,antiadhesion,and so on,thus can be used in a broad medical field.In this paper,we briefly overview the structure and function of several kinds of lipopeptides and briefly summarize their application in the field of vaccine,hoping can promote the research of the new vaccines and adjuvants.