摘要
微生物脂肽是近几年研究的热点之一。天然微生物脂肽是由微生物产生的次级代谢产物,合成微生物脂肽则是在天然微生物脂肽的结构基础上进行结构修饰获得。现有研究表明,微生物脂肽具有显著的疫苗或佐剂活性,并且能发挥抗菌、抗病毒、抗肿瘤、抗黏附等作用,具有广阔的应用前景。本文通过对几种微生物脂肽的结构和功能进行简要总结,概述脂肽在疫苗领域的应用,为新疫苗和佐剂的设计提供借鉴。
Lipopeptides is one of the hot spot of research in recent years.Natural lipopeptides are the secondary metabolites produced by prokaryotes,while synthetic lipopeptides is based on the natural lipopeptide’s structure and retains the core structure with modified active group.Recent studies have shown that lipopeptides has significant vaccine/adjuvant activity,and have the ability of antibacterial,antivirus,antitumor,antiadhesion,and so on,thus can be used in a broad medical field.In this paper,we briefly overview the structure and function of several kinds of lipopeptides and briefly summarize their application in the field of vaccine,hoping can promote the research of the new vaccines and adjuvants.
作者
李笋
张卫军
孙思
金喆
戚远通
邹全明
李海波
LI Sun;ZHANG Weijun;SUN Si;JIN Zhe;QI Yuantong;ZOU Quanming;LI Haibo(Department of Microbiology and Biochemical Pharmacy,Army Medical University,Chongqing 400038,China;Department of Pharmacy,Army Medical University,Chongqing 400038,China)
出处
《免疫学杂志》
CAS
CSCD
北大核心
2020年第9期821-828,共8页
Immunological Journal
基金
国家自然科学基金面上项目(31670936)
陆军军医大学科技创新能力提升专项(2020XGBD06)。
关键词
脂肽
疫苗和佐剂
应用
作用机制
Lipopeptides
Vaccines and adjuvants
Application
Mechanism