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复方威麦宁胶囊长期毒理实验安全性评价 被引量:1

Safety Evaluation of Long-Term Toxicological Experiment of Compound Weimaining Capsule
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摘要 目的从大鼠长毒性实验研究评价复方威麦宁胶囊的药理毒理学安全性指数。方法SD大鼠随机分为高、中、低3个剂量组和对照组,连续给药6个月,在给药第16周和26周检测动物基本情况、血常规、肝肾功能、血糖血脂、凝血指标、各脏器组织指数和病理学组织检查,并观察停药后第6周各指标的恢复情况。结果在给药的中期和末期,中、低药物剂量组未发现可致实验大鼠毒性症状和各项指标异常,高剂量药物组血液生化指标发现心、肝脏、肾有异常,但病理切片显示无异常,以上指标在撤药后恢复期复查均正常,与空白对照组比较,差异无统计学意义(P>0.05)。结论复方威麦宁胶囊对实验动物长毒性实验研究,在治疗剂量范围内用药安全。 Objective To evaluate the pharmacological and toxicological safety index of Compound Weimaining Capsule from the long toxicity experimental study of rats.Methods SD rats were randomly divided into four groups:Compound Weimaining Capsule high,middle and low dose groups and control group.The rats were continuously administered for 6 months.The basic conditions,blood routine,liver and kidney function,and blood glucose were measured at the 16 th and 26 th week of administration.Blood lipids,coagulation parameters,organ index and pathological examination of the organs were observed,and the recovery of each index at the 6 th week after stopping the drug was observed.Results In the middle and late stages of drug administration,no significant toxicity or abnormality of the experimental rats was found in the Compound Weimaining Capsule middle and low dose groups.The blood biochemical indicators of the middle high dose group showed abnormalities in heart,liver and kidney,with no pathological sections.No abnormalities were observed.The above indicators were normal after the drug withdrawal.Compared with the blank control group,the difference was not statistically significant(P>0.05).Conclusion Compound Weimaining Capsule is safein the therapeutic dose rangeonexperimentalanimals.
作者 袁建平 吕艳 李玲瑞 杜瑶 YAN Janping;LYU Yan;LI Linrui;DU Yao(The First People's Hospital of Qujing,Qujing 655000,Yunnan,China)
出处 《中华中医药学刊》 CAS 北大核心 2020年第8期233-236,共4页 Chinese Archives of Traditional Chinese Medicine
基金 云南省科技厅重点新产品开发专项项目(2016BC011)。
关键词 复方威麦宁胶囊 长毒 大鼠 Compound Weimaining Capsule long toxicity rat
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