天枢穴深刺对中风后便秘的临床观察及对血清SP、VIP的调节作用

The Regulation Mechanism and Clinical Observation of Acupuncting Tianshu Point Deeply on the Serum SP、VIP of Constipation after Apoplexy

目的观察深刺双侧天枢穴对中风后便秘患者的临床疗效及脑肠轴的调控机制。方法将90例中风后便秘患者随机分为双侧天枢穴组,支沟组和西药组,每组各30例。治疗前后进行症状积分评定表、大便性状评分(BSFS)、便秘患者临床评分量表(CCS)评定,并使用ELISA法测定血清中SP和VIP含量。结果天枢组临床疗效、症状及性状积分、CCS评分等均优于支沟组和西药组,且患者血清SP含量高于其他两组,VIP含量低于后两组,具有统计学意义(P<0.05)。结论深刺双侧天枢穴治疗中风后便秘疗效显著,可有效改善临床症状。深刺天枢可能通过升高血清SP含量、降低VIP含量,调控脑肠轴,改善便秘症状。

Objective To explore the regulation mechanism and clinical effect of deep acupuncture on bilateral tianshu points on cerebral and intestinal axis of poststroke constipation.Methods 90 patients with poststroke constipation were randomly divided into bilateral tianshu acupoint group,zhigou group and western medicine group,with 30 cases in each group.Before and after treatment,the symptom score scale,stool trait score(BSFS),constipation clinical score scale(CCS)were used,and the serum SP and VIP contents were determined by ELISA.Results The clinical efficacy,symptom and character score and CCS score of the tianshu group were better than those of the zhigou group and the western medicine group,and the serum SP content of the patients was higher than those of the other two groups,while the VIP content was lower than those of the other two groups,which was statistically significant(P<0.05).Conclusion Acupuncturing on both sides of tianshu acupoints deeply is effective in the treatment of poststroke constipation and can effectively improve the clinical symptoms.By increasing the content of SP in serum and decreasing the content of VIP,shenqitianshu may regulate the brain and intestinal axis and improve the symptoms of constipation.