摘要
目的探讨重症肌无力(myasthenia gravis,MG)患者卫气功能的特点,为临床用药提供科学依据。方法通过流式细胞技术检测25例初诊为重症肌无力患者的淋巴细胞亚群,分析CD4^+T细胞、CD8^+T细胞、CD16^+56 T细胞等指标的变化,观察MG患者卫气功能的特点。结果MG患者表现为CD4^+T细胞功能的活跃,CD8^+T细胞的功能抑制以及CD16^+56 T细胞功能的抑制。结论MG患者存在着以CD16+56 T细胞为代表的固有免疫系统的功能抑制和以CD4^+T为代表的获得性免疫系统的功能亢进。
Objective To investigate the characteristics of defense qi in patients with MG,and to provide scientific evidence for clinical drug use.Methods Flow cytometry was used to detect the lymphocyte subsets of 25 patients with newly diagnosed myasthenia gravis.The changes of CD4^+T cells,CD8^+T cells and CD16^+56 T cells were analyzed.The characteristics of defense qi in MG patients were observed.RESULTS MG patients showed active CD4^+T cell function,functional inhibition of CD8^+T cells,and inhibition of CD16^+56 T cell function.Conclusion MG patients have functional inhibition of the innate immune system represented by CD16^+56 T cells and hyperfunction of the acquired immune system represented by CD4^+T.
作者
张树森
宋先红
唐桂华
周徐
况时祥
Zhang Shusen;Zhou Xu;Song Xianhong;Tang Guihua;Kuang Shixiang(Department of Neurology,Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine,Guiyang,Guizhou 550003,China)
出处
《世界科学技术-中医药现代化》
CSCD
北大核心
2020年第6期2019-2023,共5页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
贵阳中医学院基金资助课题([2011]06):补脾强力复方对重症肌无力Ⅰ、Ⅱ型T细胞亚群及免疫球蛋白影响的临床观察,负责人:张树森
科学技术平台及人才团队计划资助课题([2018]5605):贵州省重症肌无力中西医综合诊治技术研发科技创新人才团队,负责人:况时祥
国家自然科学基金委员会地区基金项目(81760815):胸腺髓质上皮细胞调控Treg细胞发育分化与重症肌无力相关性及益气解毒复方干预研究,负责人:况时祥。
关键词
重症肌无力
淋巴细胞亚群
卫气
Myasthenia gravis
lymphocyte subsets
defense qi
