心理干预联合药物治疗丘疹脓疱型玫瑰痤疮的疗效观察

Efficacy of Psychological Intervention Combined with Medicine in the Treatment of the Patients with Papulopustular Rosacea

目的评价心理干预联合药物治疗丘疹脓疱型玫瑰痤疮的临床疗效。方法选取2018年4月-2019年11月本科门诊确诊的丘疹脓疱型玫瑰痤疮患者80例,随机分为对照组和观察组,每组40例。两组患者均给予多西环素口服和甲硝唑凝胶外用基础治疗,观察组在此基础上采用心理干预措施,连续治疗8周。观察两组患者治疗前后的临床症状积分、皮肤病生活质量指数(DLQI)评分、抑郁自评量表(SDS)评分及焦虑自评量表(SAS)评分,比较两组患者的临床疗效。结果治疗8周后,观察组无病例缺失,对照组3例缺失。同时两组患者红斑、丘疹脓疱、瘙痒等症状积分明显降低,且观察组症状改善优于对照组,差异具有统计学意义(P<0.05);两组患者DLQI、SDS、SAS评分明显下降,观察组明显低于对照组,差异具有统计学意义(P<0.05);观察组有效率(90.00%)高于对照组(70.27%),差异具有统计学意义(P<0.05)。结论采用心理干预联合药物治疗可提高丘疹脓疱型玫瑰痤疮患者的治疗效果,增加患者依从性,改善生活质量。

Objective To assess the efficacy of psychological intervention combined with medicine in the treatment of the patients with papulopustular rosacea.Methods A total of 80 patients with papulopustular rosacea from April 2018 to November 2019 were divided into the observation group(40 patients) and control group(40 patients).The patients in two groups were treated with doxycycline for oral therapy and metronidazole gel for external use.And the patients in observation group were given with mental nursing.After 8 weeks,the clinical efficacy of the two groups was compared.And the scores of symptoms(erythema,papule,pustules,pruritus),Dermatology life quality index(DLQI),Self-rating depression scale(SDS) and Self-rating anxiety scale(SAS) were compared between the two groups.Results After 8 weeks of treatment,there was no case deletion in the observation group and 3 in the control group.After treatment,the scores of erythema,papule pustule,pruritus and other symptoms of the two groups were significantly improved,and the scores of clinical symptoms of the observation group were lower than those of the control group,and there was a significant difference between the two groups(P<0.05).After treatment,the observation group DLQI,SAS and SDS scores were significantly lower than the control group(P<0.05).The total effective rate in the observation group was 90.00%,which was higher than that in the control group(70.27%),with a significant difference(P<0.05).Conclusion Psychological intervention combined with medicine in the treatment of the patients with papulopustular rosacea is more effective than medicine alone to improve compliance and quality of life.