承德市2013-2019年新发现HIV/AIDS病例首次CD4^+T淋巴细胞检测情况分析

Analysis of the First Detection of CD4^+T Lymphocytes in New HIV/AIDS Cases in Chengde from 2013 to 2019

目的分析新发现的HIV/AIDS患者的CD4^+T淋巴细胞绝对值与人口基础信息的关系,为承德市HIV/AIDS病例感染评估、抗病毒治疗及艾滋病防治深入工作提供依据。方法对符合条件的病例信息和CD4^+T淋巴细胞绝对值进行录入和整理,应用SPSS24.0软件对数据进行分析,两组间比较用Mann-Whitney U检验,多组间比较用Kruskal-Walis秩和检验进行检验。结果487例HIV/AIDS患者中,首次CD4^+T淋巴细胞检测均值(342.55±229.38)个/μL,<200个/μL占27.31%,不同性别、文化程度的HIV/AIDS病例首次CD4^+T淋巴细胞绝对值比较,差异无统计学意义(P>0.05)。不同年龄、不同婚姻状况、不同感染途径、不同职业HIV/AIDS病例首次CD4^+T淋巴细胞绝对值比较,年龄≤29岁组、未婚组、同性传播组、职业为工人组,其首次CD4^+T淋巴细胞绝对值较其他组高,差异有统计学意义(P<0.05)。结论影响承德市2013-2019年HIV/AIDS患者首次CD4^+T淋巴细胞绝对值均值的因素主要是年龄、学历、婚姻状况、感染途径、人群分类。所以应有针对性地调整艾滋病防治工作策略,进一步扩大检测范围,早检测、早发现、早治疗,避免HIV患者机会性感染,减少艾滋病的传播。

Objective To analyze the relationship between the absolute value of CD4^+T lymphocytes and population basic information of newly found HIV/AIDS patients,and to provide basis for the further work of HIV/AIDS infection assessment,antiviral treatment and AIDS prevention and control in Chengde.Methods The data were analyzed by SPSS24.0 software package.The comparison between the two groups was tested by Mann-Whitney U test,and the comparison between multiple groups was tested by Kruskal-walis rank sum test.Results In 487 HIV/AIDS patients,the mean value of the first CD4^+T lymphocyte test(342.55±229.38) was less than 200/μL,accounting for 27.31%.There was no significant difference in the absolute value of the first CD4^+T lymphocyte between HIV/AIDS patients with different gender and education(P >0.05).The absolute value of CD4^+T lymphocytes for the first time in HIV/AIDS cases of different ages,different marital status,different infection routes and different occupations was compared.The absolute value of CD4^+T lymphocytes for the first time in the age ≤ 29 group,unmarried group and same-sex transmission group was higher than that in the other groups(P<0.05).Conclusion The main factors influencing the mean absolute value of CD4^+T lymphocytes for the first time in HIV/AIDS patients in Chengde from 2013 to 2019 are age,education background,marital status,infection route and population classification.Therefore,our city should adjust the AIDS prevention and control strategy,further expand the scope of testing,early detection,early treatment,to avoid opportunistic infection of HIV patients,reduce the spread of AIDS in our city.