中医药在氧化应激方面对冠心病治疗研究进展

Research Progress of Traditional Chinese Medicine in the Treatment of Coronary Heart Disease with Oxidative Stress Recipe

冠状动脉粥样硬化性心脏病(Coronary heart disease)简称冠心病,是在冠状动脉粥样硬化导致管腔狭窄的基础上,冠状动脉供血不足,心肌急性、短暂性缺血、缺氧所引起的临床综合征。冠心病是心血管系统的常见病、多发病。近年来,冠心病的发病率呈逐年上升的趋势,严重危害人类的身心健康。现研究表明,在冠心病中,过量的活性氧(ROS)可能导致内皮细胞和平滑肌功能紊乱,进而致使抗氧化能力与抗氧化剂之间的不平衡。ROS还可引起炎症信号的激活和线粒体介导的凋亡,从而促进和增加冠心病的发生发展,同时人们对ROS在冠心病发病机制中的重要性和新型治疗方法的认识日益增强。中药作为一种重要的治疗资源,具有多种抗氧化活性。该文总结了中药及其有效成分和复方、中成药等中医药方法通过调节ROS治疗冠心病的研究进展。

Coronary atherosclerotic heart disease is a clinical syndrome caused by insufficient coronary artery blood supply,acute myocardial ischemia and hypoxia on the basis of coronary atherosclerosis leading to lumen stenosis.Coronary heart disease is a common and frequently-occurring disease in the cardiovascular system.In recent years,the incidence of coronary heart disease is increasing year by year,which seriously endangers human physical and mental health.The present study shows that in coronary heart disease,excessive reactive oxygen species(ROS)may lead to the dysfunction of endothelial cells and smooth muscle,which may lead to the imbalance between antioxidant capacity and antioxidants.ROS can also induce the activation of inflammatory signal and apoptosis mediated by mitochondria,thus promoting and increasing the occurrence and development of coronary heart disease.The importance of ROS in the pathogenesis of coronary heart disease and the new treatment methods are increasingly recognized.In this paper,the research progress of traditional Chinese medicine in the treatment of coronary heart disease by regulating ROS was summarized.