小檗碱干预下肢动脉硬化闭塞症的网络药理学研究被引量：3

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摘要目的利用网络药理学研究方法预测小檗碱(BBR)干预下肢动脉硬化闭塞症(ASO)的作用机制。方法利用TCMSP数据库、CTD数据库,挖掘BBR的作用靶点,通过DisGeNET、GeneCards、OMIM等数据库筛选出ASO的靶标。运用Cytoscape软件构建BBR干预ASO的“成分-靶标-疾病”网络,通过STRING数据库构建靶点蛋白相关作用网络并进行关键靶点的生物功能注释及通路分析。结果BBR可以通过干预163个靶点、155条通路干预ASO。结论BBR可能通过抑制炎性反应、保护内皮细胞等药理作用干预ASO。

作者王玉涛庞雪李安举

机构地区山东省济南市中医医院山东省千佛山医院

出处《现代中西医结合杂志》 CAS 2020年第25期2793-2796,2823,共5页 Modern Journal of Integrated Traditional Chinese and Western Medicine

基金山东省中医药科技发展计划项目(2017-299) 山东省医药卫生科技发展计划项目(2018WS478) 济南市第二届优秀卫生计生人才培养项目(济卫科外发〔2018〕8号) 济南市第三批“薪火传承231工程”培养项目(济中医药发〔2017〕11号) 张恒龙山东省名老中医药专家传承工作室建设项目(鲁卫中发展字〔2018〕1号) 迟景勋全国名老中医药专家传承工作室建设项目(国中医药人教发〔2016〕42号)。

关键词小檗碱网络药理下肢动脉硬化闭塞症有效成分靶点

分类号 R543.12 [医药卫生—心血管疾病]

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1邱红梅,杨发建,张琴,何琦,金磊,杨俊霞.小檗碱对脂代谢及血管粥样硬化的影响及机制探讨[J].重庆医科大学学报,2012,37(8):661-664. 被引量：12

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