儿茶酚胺与儿童直立不耐受的关系

Relationship between catecholamines and orthostatic intolerance in children

直立不耐受最常见类型是血管迷走性晕厥和体位性心动过速综合征。儿茶酚胺包括去甲肾上腺素和多巴胺等。去甲肾上腺素主要由交感神经的末端作为化学传递物质而被分泌,可致心率增快、心肌及血管收缩增强;多巴胺是体内合成NE的前体物质,由中枢神经系统及神经节分泌的神经递质之一,与人体的情绪及感觉有关。该文主要介绍儿茶酚胺与血管迷走性晕厥及体位性心动过速综合征发病之间的关系。

The most common types of orthostatic intolerance(OI)are vasovagal syncope(VVS)and postural tachycardia syndrome(POTS).Catecholamines(CA)include norepinephrine(NE)and dopamine(DA).Norepinephrine is mainly secreted by the end of sympathetic nerve as a neurotransmitter,which can increase heart rates and enhance contraction of myocardia and vessels;dopamine is a precursor for the synthesis of NE in the body,and is also one of the neurotransmitters secreted by the central nervous system and ganglia,which is related to the emotions and feelings of human beings.The paper mainly introduces the relationship between catecholamine and VVS and POTS.