超声电导经皮给药辅助治疗恶性肿瘤并发肺部感染的临床研究

Ultrasound Conductive Transdermal Drug Delivery in the Adjuvant Therapy of Malignant Tumors Complicated with Pulmonary Infection

目的:探讨超声电导经皮给药辅助治疗恶性肿瘤并发肺部感染的临床效果.方法:选取2018年1月-2019年10月于本院接受治疗的80例恶性肿瘤并发肺部感染的患者作为研究对象,使用随机数字表法将患者分为研究组和对照组,各40例.对照组给予常规静脉给药治疗,研究组在对照组基础上给予超声电导经皮给药辅助治疗.比较两组症状消失、住院、抗菌药物使用及实验室指标恢复正常时间,比较两组治疗效果及不良反应发生情况.结果:研究组治疗总有效率明显高于对照组(P<0.05);研究组肺部啰音、咳喘及X线阴影消失时间均明显短于对照组(P<0.05);研究组血常规、降钙素原及C反应蛋白恢复正常时间均明显短于对照组(P<0.05);研究组抗菌药物使用及住院时间均明显短于对照组(P<0.05);两组不良反应发生率比较,差异无统计学有意义(P>0.05).结论:超声电导经皮给药辅助治疗恶性肿瘤并发肺部感染患者可以显著提升治疗效果,缩短临床症状、实验室指标恢复正常时间,减少抗菌药物使用及住院时间,确保良好的安全性.

Objective:To explore the clinical effect of ultrasound conductive transdermal drug delivery in the adjuvant therapy of malignant tumor complicated with pulmonary infection.Method:A total of 80 patients with malignant tumor complicated with pulmonary infection treated in our hospital from January 2018 to October 2019 were selected as study subjects.They were divided into study group and control group using the random number table method,40 cases in each group.The control group was given conventional intravenous drug therapy,and the study group was given ultrasound conductive transdermal drug delivery adjuvant therapy on the basis of the control group.The time of symptom disappearance,hospitalization,antibiotic use and recovery of laboratory indexes were compared between the two groups.The treatment effect and the occurrence of adverse reactions were compared between the two groups.Result:The total effective rate of the study group was significantly higher than that of the control group(P<0.05).The disappearance time of pulmonary rales,cough and asthma and X-ray shadow in the study group was significantly lower than that in the control group(P<0.05).Blood routine,procalcitonin and C-reactive protein in the study group were significantly lower than those in the control group(P<0.05).The antibiotic use and hospitalization time in the study group were significantly lower than those in the control group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Ultrasound conductive transdermal drug delivery in the adjuvant therapy of patients with malignant tumors complicated with pulmonary infection can significantly improve the therapeutic effect,shorten the time for clinical symptoms and laboratory indicators to return to normal,reduce the use of antibiotics and hospital stay,and ensure good safety.