肥胖IGT人群肠道菌群特点及其作用机制与治疗的研究进展

Characteristics of Intestinal Flora in Obese IGT Population and Research Progress in Its Mechanism and Treatment

糖尿病发生前即糖耐量减低(IGT)阶段即可存在肠道菌群移位,主要表现为菌群多样性降低及菌群比例失调,且与胰岛素抵抗及血糖水平具有相关性。肠道菌群紊乱可通过多种途径影响胰高血糖素样肽-1分泌,参与肥胖、IGT甚至2型糖尿病等代谢性疾病的发生、发展。而中药、部分降糖药、热量限制的饮食方式、微生态制剂以及合理使用抗生素均可以通过调整肠道微环境,达到改善糖代谢的目的。因此,调节肠道微生态有望成为延缓甚至治疗糖尿病的新突破口。

Before the onset of diabetes mellitus,in the stage of impaired glucose tolerance(IGT),intestinal flora translocation may exist,which is mainly manifested as the decrease of microflora diversity and imbalance of microflora proportion,and is related to insulin resistance and blood glucose level.Intestinal flora disorders can affect glucagon-like peptide-1 secretion through a variety of pathways,and participate in the occurrence and development of metabolic diseases such as obesity,IGT,and even type 2 diabetes.Traditional Chinese medicine,some hypoglycemic drugs,calorie-restricted diet,microecological preparations and rational use of antibiotics can improve glucose metabolism by adjusting the intestinal microenvironment.Therefore,the regulation of intestinal microecology is expected to be a new breakthrough in delaying or even treating diabetes.