炎症指标的变化在糖尿病患者真菌感染诊断中的价值分析

Analysis of the Value of Changes in Inflammation Index in the Diagnosis of Fungal Infection in Diabetic Patients

目的探讨糖尿病合并真菌感染时常用炎症指标的变化情况。方法2013年6月—2019年7月选择入住ICU糖尿病合并感染的脓毒症患者102例,根据感染病源,分为真菌感染组、细菌感染组、合并细菌真菌感染组,所有患者均于入院后采用常规检查与治疗,统计纳入时点各项常规炎症指标,如降钙素原(PCT)、C-反应蛋白(CRP)、白细胞(WBC)等各项指标,比较组间各项指标的差异。结果细菌感染组、合并细菌真菌感染组PCT明显高于真菌感染组,差异有统计学意义(P<0.05);细菌感染组、合并细菌真菌感染组PCT差异无统计学意义(P>0.05);3组间WBC、CRP差异无统计学意义(P>0.05)。结论糖尿病患者感染时炎症指标的波动变化,特别是WBC、CRP升高,而PCT变化不明显时,提示患者可能存在真菌感染,这对糖尿病真菌感染的诊断有着重要的临床警示意义。

Objective To investigate the changes of commonly used inflammation indicators in diabetes complicated with fungal infection.Methods From June 2013 to July 2019,102 patients with sepsis who were admitted to ICU diabetes combined with infection were divided into fungal infection group,bacterial infection group,and bacterial fungal infection group according to the source of infection.All patients were admitted to the hospital after routine inspection and treatment,the routine inflammatory indicators at the time of inclusion,such as:procalcitonin(PCT),C-reactive protein(CRP)white blood cells(WBC)and other indicators,were compared.difference.Results The PCT in the bacterial infection group and the bacterial fungal infection group was significantly higher than that in the fungal infection group(P<0.05);the PCT difference between the bacterial infection group and the bacterial fungal infection group was not statistically significant(P>0.05);There was no statistically significant difference in WBC and CRP between groups(P>0.05).Conclusion The fluctuation of inflammation indicators during diabetes infection,especially the increase of WBC and CRP,and the insignificant change of PCT,suggesting that patients may have fungal infection,which has important clinical warning significance for the diagnosis of diabetic fungal infection.