阿奇霉素联合喜炎平治疗小儿肺炎支原体肺炎的疗效评估

Evaluation of the Efficacy of Azithromycin Combined with Xiyanping in the Treatment of Children with Mycoplasma Pneumoniae Pneumonia

目的探究喜炎平注射液与阿奇霉素联合用药治疗小儿肺炎支原体肺炎的临床疗效。方法选取2018年6月—2019年6月间该院收治的80例肺炎支原体肺炎患儿,将患儿按照入院先后随机分入到对照组与观察组中,各40例。对照组单纯阿奇霉素治疗,观察组在对照组的基础上增加喜炎平注射液治疗。对比观察两组患儿的临床治疗疗效。结果观察组治疗总有效率为92.50%,对照组治疗总有效率为72.50%,两组对比差异有统计学意义(χ^2=13.853,P<0.05)。治疗前两组患者IL-6、TNF-α、IgG指标水平对比(P>0.05);治疗后观察组炎症因子指标IL-6、TNF-α水平低于治疗前与治疗后的对照组(P<0.05);观察组免疫功能指标IgG水平高于治疗前与治疗后的对照组(P<0.05)。观察组患儿的退热时间、咳嗽消失时间、肺部干湿啰音消失时间、住院时间均早于对照组(P<0.05)。观察组治疗期间药物不良反应发生率20.00%,对照组为15.00%,两组药物不良反应对比(P>0.05)。结论喜炎平注射液联合阿奇霉素治疗小儿肺炎支原体肺炎疗效十分理想,显著改善患儿机体内的炎症水平,同时快速缓解患儿咳嗽等临床症状,值得推广。

Objective To explore the clinical efficacy of Xiyanping injection combined with azithromycin in the treatment of mycoplasma pneumoniae pneumonia in children. Methods From June 2018 to June 2019, 80 children with M. pneumoniae pneumonia admitted to our hospital were randomly divided into the control group and the observation group, 40 cases each according to the admission order. The control group was treated with azithromycin alone, and the observation group was treated with Xiyanping injection on the basis of the control group. Compare the clinical therapeutic effect of the two groups of children. Results The total effective rate of treatment in the observation group was 92.50%, and the total effective rate of treatment in the control group was 72.50%. The difference between the two groups was statistically significant (χ^2=13.853,P<0.05). Before treatment, the levels of IL-6, TNF-α, and IgG were compared between the two groups(P> 0.05);after treatment, the levels of IL-6 and TNF-α in the observation group were lower than those before and after treatment(P <0.05);the immune function index IgG level in the observation group was higher than that in the control group before and after treatment(P<0.05). The fever time, cough disappearance time, lung dry and wet rales disappearance time and hospitalization time in the observation group were earlier than those in the control group(P<0.05). The incidence of adverse drug reactions in the observation group during treatment was 20.00%, and that in the control group was 15.00%. Comparison of adverse drug reactions between the two groups(P >0.05). Conclusion Xiyanping injection combined with azithromycin is very effective in treating mycoplasma pneumoniae pneumonia in children. It can significantly improve the level of inflammation in children’s body, and at the same time quickly relieve the clinical symptoms of children’s cough. It is worth promoting.