西咪替丁和奥美拉唑治疗应激性胃溃疡的临床效果

Clinical Effect of Cimetidine and Omeprazole in the Treatment of Stress Gastric Ulcer

目的探讨评价西咪替丁和奥美拉唑治疗应激性胃溃疡的疗效。方法以2017年10月—2019年5月为时间段,在该院收治的应激性胃溃疡患者中选择142例作为对象。将这142例患者随机分成对照组、研究组,各71例。给予对照组患者西咪替丁治疗,给予研究组患者奥美拉唑治疗。对比评价患者的临床疗效。结果研究组总有效率97.2%高于对照组81.7%,组间数据差异有统计学意义(χ^2=12.623,P=0.000);研究组止血时间、住院时间、胃液pH值及血清胃泌素水平优于对照组(27.45±4.17)h vs (43.56±8.84)h;(17.42±5.12)d vs (24.31±5.01)d;(6.13±0.71) vs (3.12±0.57);(92.35±11.07)pg/mL vs (109.47±13.48)pg/mL,两组数据分析,差异有统计学意义(t=8.465、6.783、11.458、6.284,P=0.000、0.000、0.000、0.000);用药后,研究组生命质量各指标评分高于对照组,差异有统计学意义(P<0.05)。结论相比西咪替丁,奥美拉唑治疗应激性胃溃疡的疗效更显著。

Objective To evaluate the efficacy of cimetidine and omeprazole in the treatment of stress gastric ulcer.Methods From October 2017 to May 2019, 142 patients with stress gastric ulcer treated in the hospital were selected as subjects. 142 patients were randomly divided into a control group and a research group, with 71 in each group.Cimetidine was given to the control group and omeprazole to the study group. Compare and evaluate the clinical efficacy of patients. Results The total effective rate of the study group was 97.2% higher than that of the control group,81.7%, and the data between the groups were statistically significantly difference(χ^2=12.623, P=0.000). The hemostatic time, hospital stay, gastric juice pH, and serum gastrin levels in the study group were excellent In the control group(27.45±4.17)h vs(43.56±8.84)h;(17.42±5.12)d vs(24.31±5.01)d;(6.13±0.71) vs(3.12±0.57);(92.35±11.07)pg/mL vs(109.47±13.48)pg/mL, there was statistically significantly difference between the two groups(t=8.465,6.783,11.458,6.284,P=0.000,0.000,0.000,0.000);After the medication, the scores of various indicators of quality of life in the study group were higher than those in the control group, which was statistically significantly differencet(P <0.05). Conclusion Compared with cimetidine, omeprazole is more effective in treating stress gastric ulcer.