期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

新型异噁唑山酮素骨架螺环氧化吲哚类化合物的合成

Synthesis of Novel Isoxazole-fused Xanthone-based Spirooxindoles
下载PDF
导出
摘要 以色酮-氧化吲哚合成子(1)与硝基异噁唑苯乙烯(2),催化剂DBU作用下,经分子间Michael加成,分子内Michael加成环化反应,获得7个新型异噁唑山酮素骨架螺环氧化吲哚类化合物3a^3g,产率87%~93%,dr=8/1~15/1,其结构经1H NMR,13C NMR和HR-MS(ESI-TOF)表征。 Seven novel isoxazole-fused xanthone-based spirooxindoles(3a^3g)were synthesized via an DBU-catalyzed inter-/intramolecular Michael cycloaddition of oxindole-chromone synthons(1)with 3-methyl-4-nitro-5-alkenyl-isoxazoles(2).The yields and dr of 3a^3g were 87%~93%and 8/1~15/1,respectively.The structures were characterized by 1H NMR,13C NMR and HR-MS(ESI-TOF).
作者 景德红 韦启迪 刘雄利 JING De-hong;WEI Qi-di;LIU Xiong-li(Southwest Guizhou Vocational & Technical College for Nationalities, Xingyi 562400, China;Guizhou Medicine Edicine Edible Plant Resources Research and Developmant Center, Guizhou University, Guiyang 550025, China)
机构地区 黔西南民族职业技术学院 贵州大学贵州省药食同源植物资源开发工程技术研究中心
出处 《合成化学》 CAS 北大核心 2020年第9期820-824,共5页 Chinese Journal of Synthetic Chemistry
基金 国家自然科学基金资助项目(81760625)。
关键词 色酮-氧化吲哚合成子 硝基异噁唑苯乙烯 Michael加成环化反应 异噁唑山酮素骨架螺环氧化吲哚类化合物 合成 oxindole-chromone synthon 3-methyl-4-nitro-5-alkenyl-isoxazole Michael cycloaddition reaction isoxazole-fused xanthone-based spirooxindoles synthesis
分类号 O626.13 [理学—有机化学] O623.7 [理学—有机化学]
  • 相关文献

参考文献3

二级参考文献25

  • 1Cui C B, Kakeya H, Osada H, et al. Novel mammali- an ceU cycle inhibitors, spirotryprostatins A and B, pro- duced by Aspergillus fumigatus, which inhibit mamma- lian cell cycle at G2/M phase[J]. Tetrahedron, 1996, 52(39) :12651 - 12666.
  • 2Ding K, Lu Y, Coleska N Z, et al. Structure-based design of potent non-peptide MDM2 inhibitors [ J ]. J Am Chem Soc,2005,127(29) :10130- 10131.
  • 3Wong W H, Lim P B, Chuah C H, et al. Oxindole al- kaloids from Alstonia macrophylla [ J ]. Phytochemistry 1996,41(1) :313 - 315.
  • 4Liu J, Yu L F, Brek Eaton J, et al. Discovery of isox- azole analogues of sazetidine-A as selective a42-nico- tinic acetylcholine receptor partial agonists for the treatment of depression [ J ]. J Med Chem, 2011,54 (20) :7280 - 7288.
  • 5Mao J, Yuan H, Wang Y, et al. From serendipity to rational antitubereulosis drug discovery of mefloquine- isoxazole carboxylic acid esters [ J ]. J Med Chem, 2009,52:6966 - 6978.
  • 6Sun R, Li Y, Xiong L, et al. Design, synthesis, and insecticidal evaluation of new benzoylureas containing isoxazoline and isoxazole group [ J ]. J Agric Food Chem,2011,59 (9) :4851 - 4859.
  • 7Liu Y, Cui Z, Liu B, et al. Design, synthesis, and herbicidal activities of novel 2-cyanoacrylates contai- ning isoxazole moieties [ J ]. J Agric Food Chem,2010, 58 (5) :2685 - 2689.
  • 8Mosman T J. Rapid colorimetric assay for eellulair growth and survival:Application and cytotxicity assays [ J ]. Immunol Methods, 1983,65:55 - 63.
  • 9Alley M C, Scudiero D A, Monks A, et al. Feasibility of drug screening with panals of human tumor cell lines using a mycroculture tetrazolium assay [ J ]. Cancer Res, 1988,48:589 - 601.
  • 10GallifordC V, Scheidt K A. Pyrrolidinyl-spirooxindole natural products as inspirations for the development of potential therapeutic agents [ J ]. Angew Chem Int Ed, 2007,46 : 8748 - 8758.

共引文献40

合成化学
2020年 第9期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部