皮肤屏障修复剂对敏感性皮肤的临床疗效研究

Clinical effect of skin barrier repair agent on sensitive skin

目的采用随机、双盲、对照研究,评价以修复皮肤屏障为目的皮肤屏障修复剂在敏感性皮肤临床治疗中的有效性和安全性。方法按照纳入和排除标准,随机入选80例敏感性皮肤患者为病例组,50例正常人为对照组,均使用皮肤屏障修复剂,在使用前、使用后14、28 d进行随访观察,并由医生根据患者皮损改变、皮肤无创性检测结果等指标差异做出评估,同时全部受试者进行自我评估。应用统计学方法对各项数据进行分析。结果敏感性皮肤患者连续使用皮肤屏障修复剂28 d后经表皮失水量、角质层含水量、皮肤弹性均有改善(P<0.05),改善率分别为92.0%、76.0%、65.3%;对照组较使用前表皮油脂含量减少和皮肤弹性增强(P<0.05)。两组受试者VISIA红区无良好改善。医生评估敏感性皮肤患者干燥、潮红等临床症状和生活质量情况均好转。89.3%受试者自我评估满意度较高,未观察到严重皮肤不良反应。结论修复皮肤屏障功能对治疗敏感性皮肤病有显著的临床功效;对临床治疗敏感性皮肤过程有事半功倍效果。

Objectives A randomized,double-blind,controlled study was investigated the effectiveness and safety of skin care products for the purpose of repairing the skin barrier on the treatment of patients with sensitive skin.Methods According to the inclusion and exclusion criteria,80 patients with sensitive skin were randomly selected as the sensitive group while 50 healthy people were used as the control group,and they were all treated with skin barrier repair agent and followed up at baseline and after 14 days and 28 days.The doctors made a assessment based on the differences in the patient’s skin lesions,non-invasive test results and so on.Moreover,all subjects made self-assessment based on their own feelings.Statistical methods were applied to analyze the data.Results After 4 weeks of using the product continuously,patients with sensitive skin showed significant improvement in transepidermal water loss,Stratum Corneum Hydration and Skin Elasticity.The improvement rates were 92.0%,76.0%and 65.3%,respectively.The control group had reduced epidermal oil content and enhanced skin elasticity(P<0.05).There was no improvement in the red area of visia in the two groups of subjects.The doctors evaluated the clinical symptoms of dry and flushing and the quality of life in sensitive skin patients significantly improved.And most subjects felt comfort and satisfaction.89.3%of the subjects had high self-assessment satisfaction,and no severe skin adverse reactions were observed.Conclusion Repairing the skin barrier function has a significant clinical effect on the treatment of sensitive skin diseases,and it has a multiplier effect on the clinical treatment of sensitive skin processes.