胃肠间质瘤东西方诊治的比较与分析

Comparison and analysis of diagnosis and treatment of gastrointestinal stromal tumor between East and West

胃肠间质瘤(gastrointestinal stromal tumor,GIST)作为一种罕见的间叶组织肿瘤,虽然发病率较低,但临床治疗需求迫切,特别是对于后线进展的GIST,国内尚无有效的治疗手段。本文旨从GIST的流行病学特征、临床表现、辅助检查、病理组织学与分子标志物及治疗等5个方面,对GIST在东西方人群中诊治的差异进行比较与分析,为东方特别是中国大陆地区借鉴西方GIST的诊疗经验,尤其是新药使用经验,提供科学依据与临床经验。

Gastrointestinal stromal tumor(GIST),as a rare mesenchymal tumor,has a low incidence,but it is urgently needed for clinical treatment,especially for advanced GIST,and there is no effective treatment in China.The purpose of this review is to analyze the differences in GIST between the Eastern and Western populations from the five aspects of GIST epidemiology,clinical manifestations,auxiliary examination,histopathology and molecular markers and treatment.These comparisons and analyses provide a scientific theoretical basis and clinical experience in using new drugs for the East,especially for the China's Mainland to learn from the experience of diagnosis and treatment of Western GIST.